Ointment combination matrix for sustained-release drug delivery

Abstract

The invention discloses an ointment combination matrix for sustained-release drug delivery, and belongs to the technical field of a medicine preparation. The ointment combination matrix contains a hydrophilic surfactant, a cellulose derivative, glyceryl behenate and vaseline, wherein the matrix is ground and mixed with the medicine to prepare the ointment; the ointment is swelled under in vitro release conditions of 37 DEG C and 100rpm; the medicine is kept to release at zero level or similar zero level for a long period of time; vaseline is good in adaptability to body tissues, and has the effect of promoting wound healing; the hydrophilic surfactant absorbs body liquid, so that the combination matrix is swelled and a drug release channel can be formed; the glyceryl behenate is good in biocompatibility; the thermal stability is increased; and matrix dissolution is avoided and release of the drug is promoted due to an adhesive effect of the cellulose derivative. The ointment is suitable for dosing normal or damaged tissues, pollution and cleaning of corroded matters are avoided, the drug frequency is reduced, the medication compliance of a patient is improved, and the ointment is a sustained-release ointment preparation applied to skin, oral cavities, rectums, vaginas and the like.

Description

technical field [0001] The invention relates to an ointment combination base for sustained and controlled release administration, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Sustained-release preparations are the third-generation dosage forms developed on the basis of the concept that the curative effect of drugs is only related to the drug concentration in the body and has nothing to do with the time of administration. Sustained and controlled release preparations can reduce the fluctuation of blood drug concentration, reduce the number of administrations, improve the curative effect, reduce adverse reactions, and are easy to use, so they are more and more widely concerned by people. Traditional pharmacological studies have shown that: cardiovascular diseases, asthma, gastric acid secretion, arthritis, migraine, etc. have a circadian rhythm, such as asthma, myocardial infarction, etc., often occur in the early morning, ...

AI Technical Summary

Problems solved by technology

Topical periodontal medication mainly uses antibiotics such as nitroimidazoles and minocycline, and the dosage forms include periodontal oral patches, periodontal strips, and mouthwash liquid preparations. These dosage forms mainly have the following problems: 1) Periodontal There is a foreign body sensation when the strip is used, it is hard and uncomfortable

2) The periodontal oral patch is one piece of gum, twice a day, and the sticking property is poor in the oral environment

3) The local residence time of other liquid mouthwash preparations is short, frequent administration is required, and patient compliance is poor

However, the preparation process of nanoliposomes prepared by patent CN102166191A is cumbersome, and an organic solvent is used in the middle, which is not easy to remove, and cannot be directly administered locally in the oral cavity, and cannot be used immediately

Images