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Medical implant of magnesium alloy/conversion coating and preparation method of medical implant

A magnesium alloy and conversion coating technology, applied in the field of biomedical materials science, can solve the problems of fast corrosion rate of magnesium alloy, poor corrosion resistance of magnesium alloy, bubble diaphragm and inflammation, etc., and achieve good biocompatibility and high corrosion resistance Performance, the effect of promoting osteogenesis

Inactive Publication Date: 2015-01-14
SHANDONG JIANZHU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its active chemical properties, magnesium alloys have poor corrosion resistance and are prone to pitting corrosion. In the body fluid environment containing chloride ions, the corrosion rate of magnesium alloys is faster.
Excessive corrosion of magnesium alloys can lead to accumulation of hydrogen gas and alkalinization of the surrounding environment, leading to bubble septum and inflammation
At the same time, too fast corrosion will lead to too fast loss of mechanical properties of magnesium alloys, which cannot provide a suitable mechanical environment for hard tissue growth.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) For the pretreatment of the magnesium alloy substrate, the magnesium alloy AZ31B is selected as the substrate, and the weight percentage of each component of the magnesium alloy AZ31B is: Mg95.662, Al2.956, Si0.022, Cu0.039, Zn0 .872, Mn0.333, Be0.095, Fe0.002, Ca0.019, and made into a size of 20cm×10cm×1cm, processed by a grinder to a relatively flat surface, and then used 360#, 600#, 800 #Sandpaper polishes the surface of the sample;

[0014] (2) Nano-treatment of the surface of the magnesium alloy substrate. The magnesium alloy sample polished in step (1) is placed on a multiple high-speed rotating rolling surface nano-processing device, and the process parameters are set as follows: speed 800 rpm, pressure 2.0 MPa, the processing time is 30 minutes;

[0015] (3) Precursor solution preparation, respectively weigh 30 grams of zinc oxide, 10 grams of calcium oxide, 2 grams of cerium nitrate dissolved in 500 ml of phosphoric acid and nitric acid mixed solution (H ...

Embodiment 2

[0019] (1) For the pretreatment of the magnesium alloy substrate, the magnesium alloy AZ31B is selected as the substrate, and the weight percentage of each component of the magnesium alloy AZ31B is: Mg95.662, Al2.956, Si0.022, Cu0.039, Zn0 .872, Mn0.333, Be0.095, Fe0.002, Ca0.019, and made into a size of 20cm×10cm×1cm, processed by a grinder to a relatively flat surface, and then used 360#, 600#, 800 #Sandpaper polishes the surface of the sample;

[0020] (2) Nano-treatment of the surface of the magnesium alloy substrate. The polished magnesium alloy sample in step (1) is placed on a multiple high-speed rotating rolling surface nano-processing device, and the process parameters are set as follows: speed 1000 rpm, pressure 3.0 MPa, the processing time is 60 minutes;

[0021] (3) Precursor solution preparation, respectively weigh 35 grams of zinc oxide, 20 grams of calcium oxide, 4 grams of cerium nitrate dissolved in 500 ml of phosphoric acid and nitric acid mixed solution (H ...

Embodiment 3

[0025](1) For the pretreatment of the magnesium alloy substrate, the magnesium alloy AZ31B is selected as the substrate, and the weight percentage of each component of the magnesium alloy AZ31B is: Mg95.662, Al2.956, Si0.022, Cu0.039, Zn0 .872, Mn0.333, Be0.095, Fe0.002, Ca0.019, and made into a size of 20cm×10cm×1cm, processed by a grinder to a relatively flat surface, and then used 360#, 600#, 800 #Sandpaper polishes the surface of the sample;

[0026] (2) Nano-treatment of the surface of the magnesium alloy substrate. The magnesium alloy sample polished in step (1) is placed on a multiple high-speed rotating rolling surface nano-processing device, and the process parameters are set as follows: speed 1200 rpm, pressure 4.0 MPa, the processing time is 90 minutes;

[0027] (3) Precursor solution preparation, respectively weighing 40 grams of zinc oxide, 22 grams of calcium oxide, 4 grams of cerium nitrate dissolved in 500 ml of phosphoric acid and nitric acid mixed solution (...

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Abstract

The invention relates to a medical implant of a magnesium alloy / conversion coating and a preparation process of the medical implant. The implant consists of three parts, namely a magnesium alloy AZ31B serving as a matrix, a surface nanocrystallized transition layer and a conversion coating, wherein the conversion coating comprises the following components: Zn3(PO4)2.4H2O, Zn2Mg(PO4)2.4H2O, CaHPO4.2H2O and CePO4.H2O. The process comprises the following steps: forming the nanocrystallized layer on the surface of the magnesium alloy by adopting a multiple high-speed revolution rolling surface nanocrystallization process, and synthesizing the conversion coating on the nanocrystallized surface layer of the magnesium alloy by utilizing a hydrothermal reaction, thereby preparing the medical implant of the magnesium alloy / conversion coating. The implant has high corrosion resistance and has good biocompatibility, and the requirement on clinical application of the implant is met.

Description

technical field [0001] The invention relates to a magnesium alloy / conversion film medical implant and a preparation method thereof, belonging to the field of biomedical material science. Background technique [0002] Biomedical materials are materials used for diagnosing, treating, repairing or replacing diseased tissues and organs of living organisms, or improving their functions. It is usually used for human hard tissues such as teeth, bones, joints, etc. and soft tissues such as heart valves, meninges, peritoneum, artificial organs, etc. As a biomedical material, magnesium alloy has good mechanical properties, biocompatibility and degradability. Compared with traditional metal biomaterials such as stainless steel, cobalt-chromium-molybdenum alloy and titanium alloy, it has a density, compressive strength and elasticity closer to human bone. Modulus, can effectively avoid the stress shielding effect, is a good implant material. However, due to its active chemical propert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/04
Inventor 孙昌李静孙康宁李阳夏明慧刘科高石磊
Owner SHANDONG JIANZHU UNIV
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