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Cefquinome transfer factor emulsion and preparation method thereof

A transfer factor and cefquinome technology, applied in the field of cefquinome transfer factor emulsion and its preparation, can solve complex and diverse problems, low income, high risk, etc., to improve antibody titer and uniformity, and reduce immune stress Response, mitigation of immunosuppressive effects

Inactive Publication Date: 2014-11-19
山东省健牧生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, my country's chicken industry has continued to develop on a large scale, and the breeding level has been continuously improved. However, the pressure of animal disease prevention and control is still great
Poor vaccine prevention effect, frequent occurrence of immunosuppressive diseases, enhanced bacterial drug resistance, complex and diverse etiology of some diseases, mixed infection and other problems have resulted in high breeding costs, low income, and high risks, and have also caused serious harm to human health. certain influence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Heat 600g of white oil for injection (density 0.925g / ml) to 120°C-150°C, then add 12g of aluminum stearate to dissolve, cool to room temperature, add 40g of Span-80 and 50g of cefquinome sulfate Powder, stir and disperse, place in a colloid mill at 2900r / min×3min to disperse evenly to obtain a uniform suspension mixture, then cool to 10-15°C as the oil phase;

[0035] (2) Add 10g Tween-80 to 300g transfer factor solution (polypeptide content: 1mg / ml), dissolve and cool to 10-15°C as the water phase;

[0036] (3) Put the oil phase and water phase in a colloid mill at a ratio of 3:1, emulsify at 2900r / min for 6 minutes, cool to room temperature, and emulsify again for 4 minutes to obtain a milky white to light yellow uniform emulsion (similar to the state of milk )product.

[0037] There is no delamination after the product has been placed for 12 months;

Embodiment 2

[0039] (1) Heat 600g of white oil for injection (density 0.925g / ml) to 120°C-150°C, then add 12g of aluminum stearate to dissolve, cool to room temperature, add 40g of Span-80 and 100g of cefquinome sulfate Powder, mix and disperse, place in a colloid mill at 2900r / min×3min to disperse evenly to obtain a uniform suspension mixture, then cool to 10-15°C as the oil phase;

[0040] (2) Add 10g Tween-80 to 300g transfer factor solution (polypeptide content: 1mg / ml), dissolve and cool to 10-15°C as the water phase;

[0041] (3) Put the oil phase and water phase in a colloid mill at a ratio of 3:1, emulsify at 2900r / min for 6 minutes, cool to room temperature, and emulsify again for 4 minutes to obtain a milky white to light yellow uniform emulsion (similar to the state of milk )product. There is no delamination after the product has been placed for 12 months;

Embodiment 3

[0043](1) Heat 600g of white oil for injection (density 0.925g / ml) to 120°C-150°C, then add 12g of aluminum stearate to dissolve, cool to room temperature, add 30g of Span-80 and 100g of cefquinome sulfate Powder, mix and disperse, place in a colloid mill at 2900r / min×3min to disperse evenly to obtain a uniform suspension mixture, then cool to 10-15°C as the oil phase;

[0044] (2) Add 10g Tween-80 to 300g transfer factor solution (polypeptide content: 1mg / ml), dissolve and cool to 10-15°C as the water phase;

[0045] (3) Put the oil phase and water phase in a colloid mill at a ratio of 3:1, emulsify at 2900r / min for 6 minutes, cool to room temperature, and emulsify again for 4 minutes to obtain a milky white to light yellow uniform emulsion (similar to the state of milk )product.

[0046] There is no delamination after the product has been placed for 6 months;

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PUM

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Abstract

The invention relates to a cefquinome transfer factor emulsion and a preparation method thereof and belongs to the technical field of preparation of veterinary drugs. The cefquinome transfer factor emulsion is composed of cefquinome sulfate, a transfer factor solution, white oil, aluminium stearate, span-80 and tween-80. The cefquinome transfer factor emulsion is a W / O emulsion, is a novel formulation, can be mixed with an oily vaccine at any proportion, can alleviate immunosuppression, can improve titer and homogeneity of an antibody after vaccine immunity and can reduce immune stress reaction. In addition, the emulsion is good in stability, is free of a layering phenomenon after being stored for 6-12 months, is good in flowability and can be mixed with the oily vaccine at any proportion.

Description

technical field [0001] The invention relates to a cefquinome transfer factor emulsion and a preparation method thereof, belonging to the technical field of veterinary drug preparation. Background technique [0002] In recent years, my country's chicken industry has continued to develop on a large scale, and the level of breeding has been continuously improved. However, the pressure of animal disease prevention and control is still great. Poor vaccine prevention effect, frequent occurrence of immunosuppressive diseases, enhanced bacterial drug resistance, complex and diverse etiology of some diseases, mixed infection and other problems have resulted in high breeding costs, low income, and high risks, and have also caused serious harm to human health. certain influence. [0003] Cefquinome Sulfate (Cefquinome Sulfate) is a fourth-generation cephalosporin antibiotic for animals, molecular formula C 23 h 24 N 6 o 5 S 2 ·H 2 SO 4 , molecular weight 626.60. The chemical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61K35/28A61K39/39A61K9/107A61K47/34A61K47/44A61K47/12A61P31/04A61K31/546
Inventor 黄迪海刘霞秦卓明张再辉徐秀荣杨波盛晓丹
Owner 山东省健牧生物药业有限公司
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