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Semi-interpenetrating intelligent hydrogel and preparation method and application thereof

A semi-interpenetrating, hydrogel technology, used in pharmaceutical formulations, medical preparations with inactive ingredients, aerosol delivery, etc., can solve the problems of long response time of gel materials, and achieve improved biocompatibility, Improved mechanical performance and improved response speed

Inactive Publication Date: 2014-08-13
NANXIONG MATERIAL PRODION BASE OF CHINESE ACADEMY OF SCI GUANGZHOU CHEM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, although a lot of work has been done on the synthesis and application of intelligent hydrogels, there are still many problems to be solved. The response time of most gel materials is still too long, and the mechanical properties of gels need to be further improved. Compatibility also needs to be further improved

Method used

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  • Semi-interpenetrating intelligent hydrogel and preparation method and application thereof
  • Semi-interpenetrating intelligent hydrogel and preparation method and application thereof
  • Semi-interpenetrating intelligent hydrogel and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] The preparation process of polyethylene glycol diacrylate (PEGDAc) used in Examples 3 to 6 is as follows: 6 g of PEG was dissolved in 50 ml of dichloromethane, 1 ml of acrylic acid and 0.1 g of 2-methylaminopyridine were added, mixed evenly, and the , another 1g of N,N-dicyclohexylcarbodiimide was dissolved in 20ml of dichloromethane, slowly added to the above solution under ice-cooling, and reacted at room temperature for 48h. The reaction solution was washed once with 1M hydrochloric acid solution, twice with saturated sodium carbonate solution, and three times with distilled water, dried over anhydrous magnesium sulfate, and then rotary evaporated to obtain polyethylene glycol diacrylate, which was designated as PEGDAc. Its H 1 NMR spectrum see figure 1 , resulting in:

[0054] δ=3.58~3.63(t, 4H, -OCH 2 CH 2 ); δ=4.31~4.39(m, 2H, -CH 2 ); δ=5.77~5.80, 6.32~6.4(m, 2H,=CH 2 ); δ=6.03~6.11 (m, 1H, =CH-).

Embodiment 2

[0056] The preparation process of polycaprolactone diacrylate (PCLDAc) used in implementation 3-6 is as follows: get 10g of polycaprolactone diol and dissolve it in 100ml of dichloromethane, add 1g of triethylamine, stir well, and Under protection, another 0.75 g of acryloyl chloride was mixed with 20 ml of dichloromethane, and slowly added dropwise to the above solution under ice bath, and reacted at 40° C. for 24 hours after the dropwise addition was completed. The reaction solution was washed once with 1M hydrochloric acid solution, twice with saturated sodium carbonate solution, and three times with distilled water, dried over anhydrous magnesium sulfate and then rotary evaporated to obtain polycaprolactone diacrylate, which was designated as PCLDAc. Its H 1 NMR spectrum see figure 2 , resulting in:

[0057] δ = 1.31 ~ 1.35 (m, 2H, -CH2-); δ = 1.58 ~ 1.61 (m, 2H, -CH 2 -); δ=2.26~2.31(m, 2H, -CH 2 -); δ=3.8~3.81(t, 2H, -CH 2 -C=O); δ=4.05~4.1(t, 2H, -CH 2 -O-); δ=5....

Embodiment 3

[0061] Weigh 0.0300g of PEGDAc, 0.0200g of PCLDAc, 0.3990g of N-isopropylacrylamide, and 0.0080g of acrylamide, dissolve them in 2ml of 1,4-dioxane, mix them uniformly by ultrasonication for 15 minutes, then add 6mg of azobisisobutylcyanide, After fully mixing, freeze-thaw cycle deoxygenation, react at 65°C for 48 hours under the protection of argon, crush the reactor, soak the gel in distilled water for 4 days, change the water every day, and remove unreacted particles to obtain the composite cross-linking agent intelligent hydrogel Glue, cut into 10mm*5mm cylindrical small pieces for later use, recorded as AAm2.

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Abstract

The invention belongs to the fields of intelligent high-molecular material and preparation method thereof, and discloses a semi-interpenetrating intelligent hydrogel and a preparation method and an application thereof. With N-isopropyl acrylamide and acrylamide as polymerization monomers and with polyethylene glycol diacrylate and polycaprolactone diacrylate as crosslinking agents, the semi-interpenetrating intelligent hydrogel is obtained by carrying out a crosslinking polymerization reaction under initiation of azobisisobutyronitrile. The obtained intelligent hydrogel allows semi-interpenetrating hydrophilic channels for communicating the gel interior and the gel surface to be formed through acrylamide auto-polymerization and copolymerization, so that the response speed of the intelligent hydrogel is further improved. The obtained semi-interpenetrating hydrogel can be used for preparing drug loading and releasing materials in the biomedical field.

Description

technical field [0001] The invention belongs to the field of intelligent polymer materials and preparation thereof, in particular to a semi-interpenetrating intelligent hydrogel and a preparation method and application thereof. Background technique [0002] The rapid development of the intelligent age has brought earth-shaking changes to human life, and it has also put forward higher requirements for materials. Smart materials are new functional materials that have only appeared in the past ten years. They are sensitive to changes in the external environment and can respond accordingly. This kind of intelligent behavior has attracted increasing attention from all sides and has extremely attractive application prospects. [0003] Smart polymer hydrogels are a representative class of smart polymer materials, also known as stimuli-responsive hydrogels or sensitive hydrogels. It has a three-dimensional network structure that the traditional gel swells in water to maintain a lar...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F220/54C08F220/56C08G65/48C08G63/91A61K47/32A61K9/06
Inventor 吕满庚李朝霞
Owner NANXIONG MATERIAL PRODION BASE OF CHINESE ACADEMY OF SCI GUANGZHOU CHEM
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