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Preparation method for nanometer composite supermolecular hydrogel with photosensitivity

A supramolecular hydrogel and nanocomposite technology is applied in the field of preparation of nanocomposite supramolecular hydrogel, which can solve the problems of uneven distribution, destroying the stability of nanoparticles, and achieve good stability and good biocompatibility. , easy to apply effects

Inactive Publication Date: 2014-04-30
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the preparation process of the above-mentioned nanocomposite supramolecular hydrogel, the amphiphilic copolymer on the one hand disperses and stabilizes the nanoparticles through physical action, and on the other hand acts as a guest molecule and assembles with cyclodextrin to form a gel, so , the dual role of the amphiphilic copolymer will not only affect the gel formation process, but also destroy the stabilization of the nanoparticles during the assembly process of the amphiphilic copolymer with α-cyclodextrin, resulting in the Inhomogeneity of distribution in the formed supramolecular hydrogel

Method used

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  • Preparation method for nanometer composite supermolecular hydrogel with photosensitivity
  • Preparation method for nanometer composite supermolecular hydrogel with photosensitivity
  • Preparation method for nanometer composite supermolecular hydrogel with photosensitivity

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Mix 10g polyethylene glycol monomethyl ether (average molecular weight 5,000) with 1.24g α - Lipoic acid was added to a reaction vessel containing 100mL of dry dichloromethane, under nitrogen protection, 0.24g of 4-dimethylaminopyridine and 0.20g of triethylamine were added, and then 1.24g of N, N'-dicyclic Hexane carbodiimide, reacted at room temperature for 48h, precipitated with petroleum ether, dried the product, dissolved it in 250mL of absolute ethanol with slight heat, cooled and precipitated, filtered, dissolved and precipitated three times, and put the product at room temperature Dry under vacuum until constant weight to obtain polyethylene glycol monomethyl ether lipoate.

[0019] 0.3gHAuCl 4 4H 2 O and 3.78 g of the above-prepared polyethylene glycol monomethyl ether lipoate were dissolved in a reaction vessel containing 60 mL of dry tetrahydrofuran, and stirred at room temperature for 12 h under the protection of nitrogen in the dark. Then add 7.4mL of 0....

Embodiment 2

[0022] Add 0.2 g of HAuCl to the reaction vessel containing 100 mL of dry THF 4 4H 2 O and 2.91 g of mercapto polyethylene glycol monomethyl ether (average molecular weight: 1,000), under the protection of nitrogen, stirred at room temperature in the dark for 12 h. Then add 14.6mL of 0.2mol / L NaBH with a syringe 4 THF solution, stirred and reacted at room temperature for 8 hours, precipitated with anhydrous ether, filtered, then dissolved the precipitate in distilled water and placed in a dialysis bag with a molecular weight cut-off of MWCO 50kDa, dialyzed in a large amount of distilled water for 5 days, and finally freeze-dried , to obtain gold nanoparticles protected by a self-assembled monolayer of polyethylene glycol monomethyl ether.

[0023] At room temperature, add 7.62 g of 12% polyethylene glycol monomethyl ether self-assembled monolayer-protected gold nanoparticle aqueous solution to 0.5 g of 10% by mass concentration of polyethylene glycol monomethyl ether prepare...

Embodiment 3

[0025] Mix 10g polyethylene glycol monomethyl ether (average molecular weight 5,000) with 1.24g α - Lipoic acid was added to a reaction vessel containing 100mL of dry dichloromethane, under nitrogen protection, 0.24g of 4-dimethylaminopyridine and 0.20g of triethylamine were added, and then 1.24g of N, N'-dicyclic Hexane carbodiimide, reacted at room temperature for 48 hours, precipitated with petroleum ether, dried the product, dissolved it in 250mL of absolute ethanol with slight heat, cooled and precipitated, filtered, dissolved and precipitated repeatedly for 4 times, and put the product at room temperature Dry under vacuum until constant weight to obtain polyethylene glycol monomethyl ether lipoate.

[0026] 0.25g HAuCl 4 and 7.56 g of the above-prepared polyethylene glycol monomethyl ether lipoate were dissolved in a reaction vessel containing 100 mL of dry tetrahydrofuran, and stirred at room temperature for 12 h under the protection of nitrogen in the dark. Then add ...

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Abstract

The invention relates to a preparation method for a nanometer composite supermolecular hydrogel with photosensitivity. The preparation method comprises the following steps: reducing chloroauric acid under the action of a reducing agent in a tetrahydrofuran solvent with mercaptopolyethylene glycol monomethyl ether or polyethylene glycol monomethyl ether thioctate as a stabilizing agent so as to form a polyethylene glycol monomethyl ether self-assembled single-layer protective gold nanocomposite particle in situ; then mixing a polyethylene glycol monomethyl ether self-assembled single-layer protective gold nanocomposite particle aqueous solution with a mass concentration of 3 to 20% and an (i)alpha( / i)-cyclodextrin aqueous solution with a mass concentration of 5 to 12%; and allowing (i)alpha( / i)-cyclodextrin and polyethylene glycol monomethyl ether on the surface of nano-gold to undergo assembling so as to obtain the nanometer composite supermolecular hydrogel with photosensitivity. The method is simple and easily practicable; the prepared gold nanocomposite particle has good water dispersibility and stability, and nano-gold is uniformly distributed in the composite supermolecular hydrogel. The nanometer composite supermolecular hydrogel prepared in the invention has shear thinning performance and photosensitivity and is expected to be used as a novel injection implant functional material in the field of biomedical engineering materials.

Description

technical field [0001] The invention belongs to the field of biomedical functional materials, in particular to a preparation method of a photosensitive nanocomposite supramolecular hydrogel. Background technique [0002] Polymer hydrogels have attracted extensive attention in the fields of bioengineering and biomaterials due to their controllable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. On the other hand, due to the effect of size effect and interface effect, inorganic nanoparticles present peculiar properties, such as optical, electrical, magnetic properties and catalytic properties, etc. The field is very popular. Therefore, the nanocomposite hydrogel formed by dispersing nanometer-sized inorganic particles in the hydrogel not only combines the advantages of the two, but also endows the composite hydrogel with new properties due to the composite effect, thereby broadening its application. scope. [0003] In ...

Claims

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Application Information

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IPC IPC(8): C08L5/16C08L71/08C08K9/04C08K3/08C08J3/075C08G65/48B22F9/24A61K47/40
Inventor 赵三平赵慧高俊
Owner WUHAN TEXTILE UNIV
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