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Surface modification fiber-reinforced composite bone cement as well as preparation method and application thereof

A surface modification and bone cement technology, applied in fiber processing, textile and papermaking, medical science, etc., can solve the problems of poor interfacial bonding strength, insufficient toughness and poor degradability of bone cement, and achieve high brittleness and good biological phase. Capacitive and biodegradable, strong plasticity

Active Publication Date: 2014-03-26
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims to improve the mechanical properties and degradability of bone cement by modifying the fiber surface, so as to overcome the bottleneck problems of poor interfacial bonding strength and uneven dispersion that usually occur when fiber is modified with inorganic bone cement, and solve the problems of bone cement. Insufficient toughness, poor degradability and other shortcomings

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  • Surface modification fiber-reinforced composite bone cement as well as preparation method and application thereof
  • Surface modification fiber-reinforced composite bone cement as well as preparation method and application thereof
  • Surface modification fiber-reinforced composite bone cement as well as preparation method and application thereof

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preparation example Construction

[0069] The preparation method of the surface modified polymer fiber of the present invention comprises the following steps:

[0070] (a) provide polymer fibers;

[0071] (b) performing plasma treatment on the surface of the polymer fiber to obtain a surface plasma treated polymer fiber;

[0072] (c) placing the surface plasma-treated polymer fiber obtained in step b) in a dopa solution for surface mineralization treatment to obtain the surface-modified polymer fiber.

[0073] In the present invention, a low-temperature plasma processor is preferably used for plasma treatment.

[0074] The atmosphere of the plasma treatment is O 2 , Ar, N 2 One or a mixture of several, wherein the preferred atmosphere is O 2 atmosphere.

[0075] The power of plasma treatment is 40w-1000w, preferably 300w-600w.

[0076] The plasma treatment time is 1-600s, preferably 10-120s.

[0077] The mineralization treatment refers to treating the surface of the polymer fiber with a dopa solution to ...

Embodiment 1

[0114] Put 1g of PLGA fiber (polylactic acid-glycolic acid copolymer) into the treatment chamber of the cold plasma treatment equipment, O 2 The degree of vacuum was adjusted to 20 Pa under the atmosphere. After the vacuum degree is stable, adjust the power to 600w, and adjust the discharge treatment time to 120s. Then the automatic matcher starts to work until the reflected power is adjusted to the minimum, then starts to discharge, and automatically turns off the glow after the time is up. After the vacuum chamber is opened to the atmosphere, the fibers are taken out.

[0115] Weigh 60 mg of the PLGA fiber (polylactic acid-glycolic acid copolymer) after the above treatment, and the plasma treatment condition is O 2 Atmosphere, power 600w, time 120s) soaked in 0.2mg / mL dopamine solution (100mL), placed in 37℃, 100% humidity environment for 24h, took it out and dried it, cut it into 1mm length, and then scanned electron microscope test, such as figure 1 As shown, a large n...

Embodiment 2

[0118] Take by weighing the PLGA fiber after 100mg plasma treatment (processing method is similar to embodiment 1, and plasma treatment condition is 0 2 Atmosphere, power 300w, time 10s) Soak in 100mL of 0.2mg / mL dopamine solution, put in 37℃, 100% humidity environment for 24h, take it out and dry it, cut into 2mm sections.

[0119] Weigh 1g of self-curing calcium phosphate bone cement powder composed of calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite, add 5mg of treated fibers, mix well, add 0.3mL of 0.3% sodium hyaluronate solution, and quickly Prepare it evenly, then fill it into the mold, and place it in an environment of 37°C and 100% humidity for curing. The curing time of the composite bone cement is 8 minutes, and its compressive strength is 36MPa after drying after demoulding.

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Abstract

The invention relates to surface modification fiber-reinforced composite bone cement as well as a preparation method and an application thereof. The composite bone cement comprises solid phase components in parts by weight as follows: 90-99.9 parts of inorganic bone cement and 0.1-10 parts of surface modification polymer fiber, wherein the surface modification polymer fiber is the polymer fiber subjected to surface plasma processing and surface mineralization processing sequentially. The invention further provides the surface modification polymer fiber, a composite bone cement material and a preparation method. Mechanical properties such as compressive strength, toughness and the like of bone cement are remarkably improved by means of the surface modification polymer fiber, and the composite bone cement can be shaped randomly and can be rapidly cured in a body fluid environment, can be used as a filling material for bone injury and is a human body hard tissue repair material with a wide application prospect.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a surface-modified fiber-reinforced composite bone cement and its preparation method and application. Background technique [0002] At present, self-curing calcium phosphate bone cement has a wide application prospect in bone repair because it can undergo a curing reaction in the physiological environment of the human body, and the cured product is similar to the inorganic components in normal human bone tissue. However, pure calcium phosphate bone cement still has some problems, such as poor mechanical properties, high brittleness, and low strength, and it is mainly used for non-weight-bearing bone defects (Tao Yan, Li Dongxu, Li Yanbao. Research progress of cement. Materials Bulletin A, 2011, 25 (2): 121-123). [0003] Studies have found that introducing degradable fibers into calcium phosphate bone cement can improve the degradation performance of bone cement, and can also...

Claims

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Application Information

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IPC IPC(8): D06M10/06D06M10/10A61L27/20A61L27/18A61L27/12A61L27/02
Inventor 刘昌胜尹曼莉王靖
Owner EAST CHINA UNIV OF SCI & TECH
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