ABA-type triblock aliphatic polyester copolymer, preparation method thereof and applications thereof
A terpolymer and polymer technology, applied in the field of polymer chemistry, can solve problems such as poor solubility and short half-life, and achieve the effects of prolonging the action time, avoiding phagocytosis, and improving hydrophilicity
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[0042] The preparation of the triblock copolymer of the present invention is carried out in three steps. First reference [Zhang S. P., et al.Biomacromolecules 2003 ,4: 437-445; Yang J., et al. Biomacromolecules 2004 ,5: 209-218] Synthesize polydiacid glycol esters with hydroxyl groups at both ends by polycondensation reaction with diacid or its derivatives (methyl ester, ethyl ester or aromatic ester) and linear diol—polymer (A) . The aliphatic polyester obtained through the polycondensation reaction in the present invention is used as a raw material for the subsequent reaction, and its ideal molecular weight range is 3000-8000, and the molecular weight is mainly controlled by the feeding ratio and the time of the polycondensation reaction. Then, the polymer (A) reacts with 2-bromoisobutyryl bromide by using the reactivity of the terminal hydroxyl group of the polymer (A) to generate a macroinitiator polymer (B) with a tertiary bromine at the end. The reaction uses anhydro...
Embodiment 1
[0045] 1. Synthesis of hydroxyl-terminated polybutylene succinate PBS
[0046] Add 5.9 g (50 mmol) dimethyl succinate and 5.4 g (60 mmol) 1,4-butanediol (molar ratio 1:1.2) into a three-necked flask treated with anhydrous and anaerobic treatment, and mix the above The system was placed in an oil bath with a preset temperature of 180°C, stirring was started, and the reaction system was protected by nitrogen. After 3 h, the reaction bottle was taken out, and after the reaction bottle was slightly cooled, the catalyst tetraisopropoxytitanium (1 / 500 of the molar number of dimethyl succinate) was added. After maintaining the temperature for 0.5 h, the pressure was reduced slowly and the reaction temperature was raised to 200 °C. The reaction was terminated after depressurizing for 3-5 h. Then, in a nitrogen atmosphere, the reaction product was quickly taken out and cooled to obtain a crude product. The above crude product was dissolved in an appropriate amount of chloroform, pre...
Embodiment 2
[0052] Similar to the synthesis method in Example 1, terpolymers with different structures can be obtained by changing the synthesis conditions. The structural formula is as follows:
[0053]
[0054] The structure of the synthesized terpolymer 1-1
[0055]
[0056] Structure of terpolymer 1-2
[0057]
[0058] Structure of terpolymer 1-3
[0059]
[0060] Structure of terpolymer 2
[0061]
[0062] Structure of Terpolymer 3
[0063]
[0064] Structure of Terpolymer 4
[0065]
[0066] Structure of terpolymer 5
[0067]
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