Novel biological endocranium patch

Abstract

The invention discloses a novel biological endocranium patch which is prepared from I-type collagen, has a unique fiber structure, can absorb cerebrospinal fluid without increasing the volume, has a nutrition protection effect on nervous tissues, is good in biocompatibility, and can induce the growth of fibroblast cells and has an effect of guiding the regeneration of tissues, and meanwhile, an endocranium repairing method is simple and practicable, well in effect, and cannot increase the postoperation infection rate, so that the novel biological endocranium patch is an effective endocranium repairing material.

Description

technical field [0001] The invention relates to a novel biological dura mater patch, in particular to a freeze-dried collagen dura mater patch and application thereof. Background technique [0002] The dura mater is an important barrier to protect brain tissue, and is of great significance for maintaining the structure and functional activities of the nervous system. Trauma or craniocerebral surgery can cause dura mater defect. If it is not repaired, the wound will not heal easily, and complications such as subcutaneous fluid, cerebrospinal fluid leakage, and intracranial infection will occur; bleeding from the scalp or muscle layer can spread to the arachnoid The lower space stimulates the brain tissue, causing fever, headache, aseptic inflammation or meningeal irritation; the direct adhesion and healing of the brain tissue and the scalp increases the chance of epilepsy. Surgery to repair the dura mater and seal the subdural space can significantly reduce or prevent compli...

AI Technical Summary

Problems solved by technology

However, artificial synthetic materials can cause serious rejection reactions, and due to local tissue reactions, they can cause brain tissue irritation, scarring or encapsulation reactions, meningitis symptoms or bleeding and other serious complications. Most repair materials rely on imports, which are expensive and difficult to promote in clinical practice; although autologous tissue repair materials have good biocompatibility and low immune response, they tend to increase the time of surgery and treatment, and have been gradually replaced by heterogeneous materials; The material has good biological adaptability. In China, bovine pericardium, sheep pericardium, bovine peritoneum, porcine peritoneum, mesentery, etc. are often used clinically, but because they are usually cross-linked by glutaraldehyde or epoxy compounds, it is easy to cause cytotoxicity. Its security concerns are still an issue