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Composition containing various microelements, preparation and preparation method thereof

A technology of trace elements and compositions, applied in medical preparations containing active ingredients, drug combinations, active ingredients of fluorine compounds, etc., can solve the problems of low absorption utilization rate and large side effects

Inactive Publication Date: 2013-10-09
江西博意特科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inorganic metal compounds are also used in this application, which also has the disadvantages of large side effects and low absorption utilization rate

Method used

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  • Composition containing various microelements, preparation and preparation method thereof
  • Composition containing various microelements, preparation and preparation method thereof
  • Composition containing various microelements, preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 prepares zinc gluconate trihydrate compound:

[0061] (1) Prepare 5L of a saturated aqueous solution of zinc gluconate trihydrate crude product at 50°C;

[0062] (2) In a sound field with a frequency of 25KHz and an output power of 50W, add a mixed solution of isopropanol and acetone at 5°C while stirring, stop the sound field after adding the mixed solution, and cool down while stirring. When the temperature drops to 5°C, Stirring was stopped, and the crystal was grown at 1° C. for 6 hours. After the crystal was precipitated, it was washed and dried to obtain a white crystalline powder of zinc gluconate trihydrate crystal;

[0063] Among them, the volume of the mixed solution of isopropanol and acetone added is 10L, and the volume ratio of isopropanol and acetone is 3:1; Hour.

[0064] The X-ray powder diffraction pattern obtained by Cu-Kα ray measurement is as follows figure 1 As shown, the melting point is: 176-178°C. Its purity is 99.98% as detected...

Embodiment 2

[0065] Embodiment 2 prepares zinc gluconate trihydrate compound:

[0066] (1) Prepare 5L of a saturated aqueous solution of zinc gluconate trihydrate crude product at 45°C;

[0067] (2) In a sound field with a frequency of 20KHz and an output power of 60W, under the condition of nitrogen filling, add a mixed solution of isopropanol and acetone at 0°C while stirring, stop the sound field after adding the mixed solution, and cool down while stirring. When the temperature was lowered to 0°C, the stirring was stopped, and the crystal was grown at 1°C for 6 hours, after the crystals were precipitated, washed and dried to obtain a white crystalline powder of zinc gluconate trihydrate;

[0068] Among them, the volume of the mixed solution of isopropanol and acetone added is 20L, the volume ratio of isopropanol and acetone is 3:2, the speed of adding the mixed solution of isopropanol and acetone is 100 ml / min, and the speed of cooling is 2°C / Hour.

[0069] The X-ray powder diffract...

Embodiment 3

[0070] Embodiment 3: the injection containing multiple trace elements:

[0071] Its formula is: the content in every 1000ml is as shown in table 1:

[0072] Table 1:

[0073]

[0074] Wherein, the osmotic pressure of the injection is 17.6mOsm / L, and the pH value is 4.0-4.5.

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Abstract

The invention relates to a pharmaceutical composition, and in particular relates to a composition containing various microelements, a preparation and a preparation method thereof. The composition comprises ferrous gluconate dihydrate, a zinc gluconate trihydrate compound, copper gluconate, manganese gluconate, sodium fluoride, cobalt gluconate dihydrate, sodium iodide, sodium iodide pentahydrate, ammonium heptamolybdate tetrahydrate, chromic chloride hexahydrate and a medicine auxiliary material. The form of the pharmaceutical composition can be injection or freeze-dried powder injection. According to the invention, organic iron, organic zinc, organic copper, organic manganese and organic cobalt are adopted to replace chloride, so that not only is the property of the composition more stable, but also the adverse reaction is reduced, and the bioavailability of the medicine is increased. Therefore, the preparation provided by the invention is better in safety and more suitable for clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a composition containing various trace elements, its formulation and preparation method. Background technique [0002] The human body is composed of more than 60 elements. According to the content of elements in the human body, they can be divided into two categories: macro elements and trace elements. Any element that accounts for more than 0.01% of the total body weight, such as carbon, hydrogen, oxygen, nitrogen, calcium, phosphorus, magnesium, sodium, etc., is called a macro element; any element that accounts for less than 0.01% of the total body weight, such as iron , zinc, copper, manganese, chromium, selenium, molybdenum, cobalt, fluorine, etc., called trace elements. The content of trace elements in the human body is really negligible, such as zinc only accounts for 33 parts per million of the total weight of the human body. Iron is also only 60 parts per million. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61P3/02A61K33/20A61K33/18A61K33/16A61K31/315A61K31/295A61K31/30A61K31/28
Inventor 桂勇陈培涛
Owner 江西博意特科技有限公司
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