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Preparation method of coating having endothelium bionic function

A bionic function and coating technology, applied in the field of biomedical engineering, can solve problems such as unsatisfactory results of long-term clinical follow-up, and achieve the effects of improving biocompatibility, low preparation cost, and simple and convenient operation.

Inactive Publication Date: 2013-10-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current strategies for improving the surface modification of vascular stents only focus on improving the biocompatibility of one aspect of the stent.
The short-term implantation effect is remarkable, but the long-term clinical follow-up results are not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A. Deposition of plasma polyallylamine film

[0019] Preparation of plasma-polymerized film rich in amine groups on the surface: put the vascular stent (for example, 316L SS) into the film deposition reaction chamber, and when the reaction chamber is vacuumed to 1.00Pa, flow argon with a flow rate of 3.0sccm Gas is used as the discharge gas, and allylamine as the reaction gas is fed to make the working pressure 8.0Pa, and the plasma is carried out for 40 minutes under the conditions of RF power 50W, negative bias voltage 75V, and pulse duty ratio 50%. Polyallylamine film deposition, that is, depositing an amino-rich plasma polyallylamine film on the surface of the vascular stent, and obtaining an amine group density of 35 nmol / cm on the surface of the interventional device 2 amine-rich surface layer. B. Co-immobilization of SeDPA and heparin sodium

[0020] Dissolve SeDPA at 1.00mg / ml and heparin sodium at 8.00mg / ml in WSC solution respectively; the composition of WSC...

Embodiment 2

[0023] A. Deposition of plasma polyallylamine film

[0024] Preparation of plasma-polymerized film rich in amine groups on the surface: Put the artificial blood vessel (PET as an example) into the film deposition reaction chamber. When the reaction chamber is vacuumed to 1.00Pa, argon gas with a flow rate of 3.0sccm is introduced. As the discharge gas, allylamine was introduced as the reaction gas so that the working pressure was 8.0 Pa, and the plasma polymerization was carried out for 40 minutes under the conditions of radio frequency power 50W, negative bias voltage 75V, and pulse duty ratio 50%. Allylamine film deposition, that is, the deposition of amino-rich plasma polyallylamine film on the surface of artificial blood vessels, the density of amine groups on the surface of the interventional device is 35nmol / cm 2 amine-rich surface layer. . B. Co-immobilization of SeDPA and heparin sodium

[0025] Dissolve SeDPA at 1.00 mg / ml and sodium heparin at 8.00 mg / ml in WSC so...

Embodiment 3

[0028] A. Preparation of amino-rich surfaces based on self-polymerization of dopamine

[0029] Amino-rich dopamine polymer film preparation: the vascular stent (take Co-Cr alloy as an example) was immersed in 2.00mg / ml dopamine Tris solution, reacted at room temperature for 48h, then ultrasonically rinsed with PBS and distilled water respectively, and dried. The surface of the thin film rich in amino groups is obtained, and the density of amine groups on the surface of the interventional device is 10nmol / cm 2 amine-rich surface layer.

[0030] B. Co-immobilization of SeDPA and heparin sodium

[0031] Dissolve SeDPA at 1.00 mg / ml and sodium heparin at 8.00 mg / ml in 1 μM-500 μM poly-lysine Tris solution, react for 1 min-12 h and mix to form a SeDPA / heparin sodium-polylysine complex. Soak the artificial blood vessel with dopamine self-polymerization film deposited on the surface in the SeDPA / sodium heparin-polylysine complex solution for 12 hours, then fully rinse with PBS and ...

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Abstract

The invention discloses a preparation method of a coating having an endothelium bionic function, which comprises the following step: fixing 3,3-diselenodipropionic acid (SeDPA) having nitrogen monoxide catalytic activity and heparin on the surface of an amino-enriched coating. The functional coating shows an endothelium-like bionic function, reflects excellent anticoagulant property, and has excellent functions of inhibiting proliferation of smooth muscle cells and promoting growth of endothelial cells.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, especially the method for preparing an endothelial bionic functional coating. Background technique [0002] Cardiovascular disease, often associated with atherosclerosis, is the leading cause of death and disability worldwide. Since Sigwart reported the first human coronary artery stent implantation in 1987, metallic vascular stent implantation has become one of the most common treatments for severe cardiovascular disease. However, stent expansion easily damages the surrounding vascular tissue. Vascular tissue trauma leads to thrombosis, inflammation, vascular intimal hyperplasia, and matrix deposition / vascular remodeling. The results of 3-6 months of implantation show that the rate of in-stent restenosis is as high as 20-30%. [0003] Improving the biocompatibility of stents is one of the important means to reduce the restenosis rate of stents. As an ideal vascular stent, it sh...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/16A61L27/30A61L27/34A61L27/54
Inventor 黄楠杨志禄王进齐鹏凯杨莹涂秋芬王娟
Owner SOUTHWEST JIAOTONG UNIV
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