Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof

A technology for biodegrading polyester and magnesium oxide whiskers, which is applied in the fields of medical science and prostheses, can solve the problems of rapid degradation speed and strength attenuation, weak interfacial bonding force, slow degradation speed, etc., and achieve the reduction of non-infectious Sexual inflammatory response, improving mechanical strength and modulus, improving strength and toughness

Active Publication Date: 2013-09-25
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] However, the results of clinical application over the years have also proved that biodegradable polyester absorbable orthopedic internal fixation materials still have the following shortcomings: (1) The mechanical strength of the material is not enough, the toughness is poor, and it is difficult to be used as a load-bearing bone repair; (2) ) The degradation rate and strength decay of the material are too fast in the early stage, and the degradation rate is too slow in the later stage. The weak acidity of the degradation product can easily lead to aseptic inflammatory reactions; (3) The material has poor hydrophilicity and the cell affinity is not ideal; (4) X-ray no development
However, the currently used inorganic fillers are often granular, which can improve the mechanical strength of biodegradable polyesters, but cannot improve the toughness of biodegradable polyesters. osteogenic activity
In addition, it is well known that the inorganic filler and the biodegradable polyester in the inorganic filler / biodegradable polyester composite are usually physically combined, and the interfacial bonding force between the inorganic filler and the matrix is ​​weak, so that the inorganic filler is dispersed in the biodegradable polyester matrix. Inhomogeneous and easy to agglomerate, which eventually leads to the failure of the ideal mechanical properties of the inorganic filler / biodegradable polyester composite

Method used

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  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof
  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof
  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of magnesium oxide whisker

[0057] Step (1): Na with a concentration of 0.5mol / L 2 CO 3 Under the condition of stirring at 800rpm, the concentration of 0.5mol / L MgCl was added dropwise at a rate of 2mL / min. 2 solution; after the dropwise addition, continue to stir for 15 minutes, let stand and age for 24 hours, filter with suction and wash with distilled water 4 times, and dry in a vacuum oven at 80°C to obtain magnesium carbonate whiskers;

[0058] Step (2): Put the magnesium carbonate whiskers obtained in step (1) into a muffle furnace for calcination. The calcination conditions are as follows: from room temperature to 800°C at a rate of 2°C / min and keep it warm for 2 hours, and when it is cooled to 450°C Take out the crucible and quickly put it in a desiccator to cool down to room temperature to obtain magnesium oxide whiskers (MgO whiskers).

Embodiment 2

[0059] Embodiment 2: the preparation of magnesium oxide whisker

[0060] Step (1): Na with a concentration of 0.5mol / L 2 CO 3 Under the condition of stirring at 1200rpm, the concentration of 0.5mol / L MgCl was added dropwise at a rate of 3mL / min. 2 solution; after the dropwise addition, continue to stir for 30 minutes, let stand and age for 24 hours, filter and wash with distilled water 5 times, and dry in a vacuum oven at 80°C to obtain magnesium carbonate whiskers;

[0061] Step (2): Put the magnesium carbonate whiskers obtained in step (1) into a muffle furnace for calcination. The calcination conditions are as follows: from room temperature to 380°C at a rate of 3°C / min and keep warm for 30min, then at 5°C / min Raise the rate to 700°C and keep it warm for 2 hours. When it cools down to 400°C, take out the crucible and quickly put it in a desiccator to cool to room temperature to obtain magnesium oxide whiskers (MgO whiskers).

[0062] The morphology of the as-prepared mag...

Embodiment 3

[0063] Embodiment 3: the magnesium oxide whisker of surface grafting polylactic acid is prepared by direct dehydration polycondensation method

[0064] Step (1): In a three-necked flask, disperse 10 g of vacuum-dried MgO whiskers (prepared in Example 2) in 200 ml of toluene, add 1 g of catalyst zinc oxide under the condition of stirring at 600 rpm, and then slowly Add 200g of L-lactic acid, after the dropwise addition, azeotropic dehydration reaction at 110°C for 12h;

[0065] Step (2): After the above reaction is completed, centrifuge the product at 800rpm, remove the supernatant, and take the lower layer of solid product, then add chloroform to dissolve, centrifuge, filter, and wash the solid product for more than 5 times to remove the lactic acid adsorbed on the surface of the solid product Monomers and polylactic acid oligomers; finally, the solid product was collected by high-speed centrifugation and dried in vacuum to obtain MgO whiskers (g-MgO whiskers) grafted with pol...

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Abstract

The invention discloses a magnesium oxide whisker / biodegradable polyester composite material and its preparation method and an application thereof. The composite material contains 0.1-60 wt% of magnesium oxide whisker and 40-99.9 wt% of biodegradable polyester. The magnesium oxide whisker / biodegradable polyester composite material provided by the invention has excellent mechanical properties, good biocompatibility and bone healing-promoting capability. Alkalinity of the magnesium oxide whisker also can regulate and control degradation rate of the biodegradable polyester, neutralize its acidic degradation products and reduce inflammatory response. The magnesium oxide whisker / biodegradable polyester composite material is a novel bone tissue repair material with an excellent osteogenic activity. The preparation method is a solution blended process or a melt blending method by using the magnesium oxide whisker and the biodegradable polyester as raw materials, or an in situ polymerization method by using the magnesium oxide whisker and a cyclic ester monomer as raw materials. According to the invention, preparation cost of the composite material is low; the preparation method is simple; condition is mild; and the preparation method is easy for industrial production.

Description

technical field [0001] The invention belongs to the field of bone tissue repair materials, in particular to a magnesium oxide whisker / biodegradable polyester composite material and its preparation method and application. Background technique [0002] Bone trauma is one of the common diseases in clinical surgery. Lesions and damage of bone tissue directly affect people's quality of life. Therefore, the repair of bone tissue damage has always been a research topic that people pay close attention to. Biodegradable polyesters (such as polylactide, polyglycolide, etc.) are a class of polymer materials that have been approved by the US FDA (Food and Drug Administration, FDA) for the manufacture of biomedical materials. It has attracted much attention and is currently the most clinically used absorbable orthopedic internal fixation material. Biodegradable polyester absorbable orthopedic internal fixation materials have the characteristics of easy molding and processing, good initi...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L69/00C08K7/08C08K3/22C08G63/08C08G63/78C08G64/30A61L27/44A61L27/50
Inventor 罗丙红文伟刘桦周长忍
Owner JINAN UNIVERSITY
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