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Phosphoryl choline polymer containing aldehyde group and preparation method and application thereof

A technology for phosphorylcholine and polymers, applied in the field of phosphorylcholine polymers and their preparation, capable of solving problems such as complex processes and harsh conditions, and achieving the effects of simple preparation methods, mild conditions, and improved biocompatibility

Inactive Publication Date: 2013-09-04
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is necessary to introduce trimethoxysilyl groups in phosphorylcholine polymers under anhydrous conditions, which is a complex process under harsh conditions.

Method used

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  • Phosphoryl choline polymer containing aldehyde group and preparation method and application thereof
  • Phosphoryl choline polymer containing aldehyde group and preparation method and application thereof
  • Phosphoryl choline polymer containing aldehyde group and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of aldehyde-containing phosphorylcholine polymers:

[0033] Weigh methacrolein monomer and 2-methacryloyloxyethyl phosphorylcholine monomer (MPC) in a molar ratio of 3:7, dissolve and mix them in distilled water to obtain a mixed solution of monomers, and mix the total monomers The 1% potassium persulfate of quality dissolves with distilled water to obtain initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 24 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D Bag dialysis; finally, the dialyzed sample was freeze-dried at -50°C to obtain aldehyde group-containing phosphorylcholine polymer.

[0034] The reaction equation of the present embodiment is as follows:

[0035]

[0036] Preparation of imitat...

Embodiment 2

[0041] The phosphorylcholine polymer containing aldehyde group prepared in Example 1 and phenylenediamine are mixed evenly at 0.5: 1 by aldehyde group and amine group molar ratio, and then coated on the surface of the chitosan material, and then solidified at 20°C After 10 hours of treatment, a coating surface with a membrane structure imitating the outer layer of cells is obtained.

[0042] Compared with the chitosan material without coating treatment, the advancing angle and the receding angle of the chitosan treated by the coating treatment in this embodiment are all reduced, because the hydrophilic Phosphorylcholine polymers with good properties are fixed on the surface of chitosan through the reaction of aldehyde groups and amino groups to obtain a surface with a structure imitating the outer membrane of cells, which significantly improves its hydrophilicity, and its advancing angle and receding angle are obvious. reduce.

Embodiment 3

[0044] The aldehyde group-containing phosphorylcholine polymer prepared in Example 1 and triethylenetetramine are mixed uniformly at 1.2:1 by aldehyde group and amine group molar ratio, and then coated on the surface of the chitosan material, then at 100 ° C After curing for 8 hours, a coating surface with a membrane structure imitating the outer layer of cells was obtained.

[0045] Compared with the chitosan material without coating treatment, the advancing angle and the receding angle of the chitosan treated by the coating treatment in this embodiment are all reduced, because the hydrophilic Phosphorylcholine polymers with good properties are fixed on the surface of chitosan through the reaction of aldehyde groups and amino groups to obtain a surface with a structure imitating the outer membrane of cells, which significantly improves its hydrophilicity, and its advancing angle and receding angle are obvious. reduce.

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Abstract

The invention discloses a phosphoryl choline polymer containing aldehyde group, and the polymer is a binary copolymer composite synthesized of Vinyl monomers containing aldehyde group and Vinyl monomers containing phosphorus acyl choline through radical polymerization. Furthermore, the invention discloses the preparation method and the application of the polymer. The polymer is used for coating the surface of to-be-decorated material after being mixed with polyamino material, the reaction of the aldehyde group and the amidogen in the coating layer are controlled by temperature, so as to enable the density of the coating layer to be increased, and achieve the purpose of fixing phosphoryl bile bases on the surface of the material and obtain a coating layer with a structure imitating of cell outer membrane. The protein absorption and blood platelet adhesion of the coating layer are remarkably decreased, the biocompatibility is remarkably improved, and the phosphoryl choline polymer has great academic values and broad application prospects in the filed of tissue engineering, drug controlled release, gene therapy, biosensor and the like.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and specifically relates to an aldehyde group-containing phosphorylcholine polymer and a preparation method and application thereof. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers 2010, 79:724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino groups on chitosan molecules help to adsorb various toxins in blood, and can be used as hemoperfusion materials (Chemical Journal of Chinese Universities, 2002, 23: 75-77; Journal of Microencapsulation 1993, 10: 475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as hemodialysis material (Journal of Applied Polymer Science 1992...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/36C08F220/60C08F216/34C08F220/28C08F220/58A61L27/34A61L27/50A61K47/32A61K48/00
Inventor 宫铭徐强强熊善新汪晓芹吴伯华褚佳
Owner XIAN UNIV OF SCI & TECH
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