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Veterinary tiamulin suspension injection and preparation method thereof

A technology for suspending injection and tiamulin, which is applied in the directions of inactive medical preparations, antibacterial drugs, and liquid delivery, etc., can solve the problems of first-pass effect, obvious side effects, strong irritation, etc. Achieve the effect of promoting and applying value of important reagents

Active Publication Date: 2014-09-24
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of tiamulin in my country are limited to conventional soluble powders and premixes. The application of traditional dosage forms has disadvantages such as inaccurate dosage, first-pass effect, and low bioavailability. Tiamulin itself is highly irritating to the respiratory tract of animals, and administration as a premix will cause severe coughing in animals, with obvious side effects. The dosage form plays a decisive role in the application of veterinary tiamulin

Method used

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  • Veterinary tiamulin suspension injection and preparation method thereof
  • Veterinary tiamulin suspension injection and preparation method thereof
  • Veterinary tiamulin suspension injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 20% tiamulin suspension

[0044] The formula of 20% tiamulin suspension is as follows:

[0045] Tiamulin 20g;

[0046] Gum Arabic 10g;

[0047] PVPK30 1g;

[0048] Tween80 0.1g;

[0049] Sodium citrate 0.9g;

[0050] Sodium metabisulfite 0.2g;

[0051] Disodium edetate 0.05g;

[0052] Methylparaben 0.18g;

[0053] Propyl p-hydroxybenzoate 0.02g;

[0054] Add water for injection to 100mL.

[0055] According to the above prescription, tiamulin is measured and mixed with various auxiliary materials under aseptic conditions, and ground by a colloid mill to prepare tiamulin suspension injection. The suspension was left for 30 minutes without stratification. After being left for 6 hours, the sedimentation volume ratio was 99.2%. After standing for a period of time until the sedimentation surface no longer changed, the sedimentation volume ratio was measured to be 90.6%.

[0056] Take out the suspension with No. 7, 8, 9, and 12 needles, and the experiment...

Embodiment 2

[0062] Example 2 20% tiamulin suspension

[0063] The formula of 20% tiamulin suspension is as follows:

[0064] Tiamulin 20g;

[0065] Gum Arabic 8g;

[0066] PVPK30 0.8g;

[0067] Tween80 0.3g;

[0068] Sodium citrate 0.8g;

[0069] Ascorbic acid 0.2g;

[0070] Disodium edetate 0.05g;

[0071] Methylparaben 0.18g;

[0072] Propyl p-hydroxybenzoate 0.02g;

[0073] Add water for injection to 100mL.

[0074] According to the above prescription, tiamulin is measured and mixed with various auxiliary materials under aseptic conditions, and ground by a colloid mill to prepare tiamulin suspension injection. The suspension was left for 30 minutes without stratification, and after 6 hours, the sedimentation volume ratio was 99%, and when it was left for a period of time until the sedimentation surface no longer changed, the sedimentation volume ratio was measured to be 90.2%.

[0075] Take out the suspension with No. 7, 8, 9, and No. 12 needles, and the experimental result...

Embodiment 3

[0081] Example 3 20% tiamulin suspension

[0082] The formula of 20% tiamulin suspension is as follows:

[0083] Tiamulin 20g;

[0084] Gum Arabic 6g;

[0085] PVPK30 0.6g;

[0086] Tween80 0.25g;

[0087] Sodium citrate 0.3g;

[0088] Thiourea 0.2g;

[0089] Disodium edetate 0.05g;

[0090] Methylparaben 0.18g;

[0091] Propyl p-hydroxybenzoate 0.02g;

[0092] Add water for injection to 100mL.

[0093] According to the above prescription, tiamulin is measured and mixed with various auxiliary materials under aseptic conditions, and ground by a colloid mill to prepare tiamulin suspension injection. The suspension was left for 30 minutes without stratification. After being left for 6 hours, the sedimentation volume ratio was 99%. After standing for a period of time until the sedimentation surface no longer changed, the sedimentation volume ratio was measured to be 89.9%.

[0094] Take out the suspension with No. 7, 8, 9, and No. 12 needles, and the experimental...

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Abstract

The invention relates to the technical field of medicine, and discloses a veterinary tiamulin suspension injection and a preparation method thereof. The veterinary tiamulin suspension injection includes the following components in weight percent: 20% tiamulin, 6-10% suspending agent gum arabic, and 0.2-1% suspending agent polyvinylpyrrolidone , 0.1-0.3% surfactant, 0.3-0.9% flocculant and other additives and the balance of water. The tiamulin suspension injection of the invention has good stability, rapid absorption, high bioavailability and remarkable effect, and provides a novel and efficient dosage form for veterinary tiamulin.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotic drugs, and in particular relates to a veterinary tiamulin suspension injection and a preparation method thereof. Background technique [0002] Tiamulin (tiamulin / thiamutin / dynamutilin), also known as tiamulin, tiamulin, Zhiyuanjing, tiamulin, tiamulin, is truncated by the fermentation of the higher fungus Basidiomycetes Pleurotus mutilus After pleuromutilin, hydrogenated fumarate is obtained by chemical synthesis, which is a special antibiotic for livestock and poultry. The drug is a bacteriostatic antibiotic. The antibacterial mechanism is combined with the 50S subunit of the bacterial ribosome to inhibit bacterial protein synthesis. It has good antibacterial activity against a variety of Gram-positive cocci, mycoplasma and some spirochetes, especially against mycoplasma. It has special effects and maintains a high concentration in the respiratory tract where mycoplasma reproduces....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/22A61K47/36A61K47/32A61P31/04
Inventor 曾振灵黄贺贤黄显会曾东平
Owner SOUTH CHINA AGRI UNIV
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