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Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof

The technology of an immune enhancer and compound is applied in the field of organic amine compounds and their preparation to achieve the effects of improving disease resistance, enhancing specific and non-specific immunity of the body, and promoting the decomposition and utilization of muscle glycogen

Inactive Publication Date: 2015-04-22
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for now, there are very few medicines that can effectively improve the body’s immunity. There are only a few western medicines, most of which are traditional Chinese medicines, but Chinese medicines generally require long-term medication to be effective.

Method used

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  • Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof
  • Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof
  • Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The structure of test drug isopropyl n-butylamine is as follows:

[0038]

[0039] In Vitro Perfusion Experiment of Frog Heart and Rat Heart

[0040] Test drug: organic amine salt formed from isopropyl n-butylamine and p-acetamidobenzoic acid at a ratio of 1:1 (molar ratio, the same below).

[0041] Frog heart and mouse heart were perfused in the isolated ventricle, and the pulsation of the ventricular muscle was recorded with a multi-channel physiological recorder. 0.05% organic salt solution had a cardiotonic effect, and the cardiotonic effect was more obvious as the concentration of the test solution increased, and the high Low concentration (5%) is also safe for the heart and does not inhibit the beating of the heart.

[0042] Experiments on motility of isolated rabbit intestine

[0043] The test drug: the organic amine salt of isopropyl n-butylamine and p-acetamidobenzoic acid 1:1.

[0044]Prepare isolated rabbit intestines, place them in a Maxwellian bath cu...

Embodiment 2

[0064] Synthesis of 1-diethylamino-2-propanol:

[0065]

[0066] Synthetic method: Add 0.2mol of diethylamine to a 250mL four-neck flask equipped with a stirrer, reflux condenser and two dropping funnels, slowly add 0.1mol of 1-chloro-2-propanol dropwise under heating in a water bath , and then dropwise added 20ml of 40% aqueous sodium hydroxide solution, and controlled the total dropping time for 2h, then boiled and refluxed for 1h, and cooled to obtain a crude product. Sodium chloride was filtered off, the filtrate was allowed to stand for layers, and the aqueous and organic phases were separated. The aqueous phase was extracted three times with ether, and the extract was combined with the organic phase and dried overnight. Filter off the desiccant and distill to obtain the product.

[0067] refer to figure 1 and figure 2 , structure data: 1 H-NMR (400MHz, CDCl 3 )δ1.0 (m, 9H) 2.4 (t, 4H) 2.6 (d, 1H) 3.4 (m, 1H) 4.8 (s, 1H); 13 C-NMR (400MHz, CDCl 3 ) δ 13.3 (2C) ...

Embodiment 3

[0069] Synthesis of isopropyl n-butylamine:

[0070]

[0071] Synthesis method: Add 0.2mol of isopropylamine to a 250mL four-neck flask equipped with a stirrer, reflux condenser and dropping funnel, slowly add 0.1mol of 1-bromobutane dropwise under heating in a water bath, and then dropwise add Add 20ml of 40% sodium hydroxide aqueous solution, control the total dropping time for 2 hours, then boil and reflux for 1 hour, and cool to obtain the crude product. Sodium chloride was filtered off, the filtrate was allowed to stand for layers, and the aqueous and organic phases were separated. The aqueous phase was extracted three times with ether, and the extract was combined with the organic phase and dried overnight. Filter off the desiccant and distill to obtain the product.

[0072] refer to image 3 and Figure 4 , structure data: 1 H-NMR (400MHz, CDCl 3 )δ0.9(t, 3H) 1.1(d, 6H) 1.3(m, 4H) 2.0(s, 1H) 2.5(t, 2H) 3.0(m, 1H); 13 C-NMR (400MHz, CDCl 3 ) δ 13.8 (1C) 20.1 (1...

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Abstract

The invention discloses organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants. The structural formula of the compounds is shown in the description. In the formula, (1) R1 is 2-hydroxypropyl, R2 is ethyl, and R3 is ethyl; (2)R1 is 2-hydroxypropyl, R2 is hydrogen, and R3 is isopropyl; (3) R1 is n-butyl, R2 is methyl or ethyl, and R3 is methyl or ethyl; (4) R1 is n-butyl, R2 is hydrogen, and R3 is isopropyl; (5) R1 is p-hydroxy phenyl ethyl, R2 is methyl or ethyl and R3 or methyl or ethyl; or (6)R1 is p-hydroxy phenyl ethyl, R2 is hydrogen and R3 is propyl. The compounds can increase the immunity in organisms, so that the organisms can resist fermentation with viruses, parasites and bacteria; the compounds can help to treat chronic wasting diseases; the compounds can allow organisms to get strength in time and be more tolerating to resist various irritation; and the compounds can be used as metabolic enhancers, roborants and fat metabolic enhancers to reduce blood fat and help users lose weight.

Description

technical field [0001] The invention relates to the technical field of compound application, in particular to an organic amine compound used as an immune enhancer, a metabolism accelerator, and a tonic, and a preparation method and application thereof. Background technique [0002] Virus, as a pathogenic microorganism, can cause various infectious diseases and epidemics of humans and various livestock and poultry, and the diseases it causes are far more than other microorganisms. For humans, 90%-95% of common acute respiratory infections are caused by viruses. According to relevant data, viruses account for about 70%-80% of human infectious diseases. Such as common influenza, mumps, infectious hepatitis, viral enteritis, viral myocarditis, epidemic Japanese encephalitis, epidemic hemorrhagic fever, herpes zoster, measles, and AIDS are all caused by viruses. Sincerely. The virus can also integrate its own genome into the host cell, which is the cause of some tumors. New v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C215/08C07C211/08C07C215/50A61K31/133A61K31/131A61K31/137A61P37/04A61P31/12A61P3/00A61P3/06A61P3/04A23L1/30A23K1/16
Inventor 崔恒敏叶平李英伦邹平
Owner SICHUAN AGRI UNIV
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