Method for separating vitamin D3 from tachysterol T3

Abstract

The invention discloses a method for separating vitamin D3 from tachysterol T3. According to the method, high-purity vitamin D3 and tachysterol T3 are efficiently separated from a mixture containing the vitamin D3 and the tachysterol T3 by a fractional extraction method, wherein a medium polar to polar organic solvent, ionic liquid or a binary mixed solvent consisting of the ionic liquid and the medium polar to polar organic solvent serves as an extracting agent. The method has the advantages of high separation efficiency, low solvent consumption, high yield, safety, environmental friendliness, easiness in industrialized production and the like.

Description

technical field [0001] The invention relates to a method for separating compounds, belongs to the technical field of chemical engineering, and in particular relates to a method for separating vitamin D 3 tachysterol T 3 Methods. Background technique [0002] Vitamin D, also known as anti-rickets vitamin, is one of the essential vitamins for human health, normal growth and reproduction of livestock and poultry, and has the functions of regulating calcium and phosphorus metabolism, promoting bone growth, regulating cell growth and differentiation, and regulating immune function effect. Vitamin D exists in many forms, two of the most important being vitamin D 2 (ergocalciferol) and vitamin D 3 (cholecalciferol). [0003] Vitamin D 3 (Vitamin D 3 , the structural formula is as figure 1 (shown) synthesis generally starts from cholesterol, which is first transformed into 7-dehydrocholesterol through a series of chemical reactions, and then undergoes a ring-opening reaction...

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Problems solved by technology

[0004] existing vitamin D 3 The separation and purification methods are as follows: U.S. Patent US3665020 uses 3,5-dinitrobenzoyl chloride or butyryl chloride esterification crystallization separation and purification method, but this method has many steps and serious environmental pollution, and in view of the limitations of chemical separation methods , the yield is lower

Preparation of vitamin D from isomer mixture by supercritical column chromatography introduced in Chinese patent ZL99108675.9 3 or precursor vitamin D 3 The method requires high equipment and needs to be operated in a high-pressure environment, which is costly and difficult to industrialize

Chinese patent ZL200510040330.4 reports the separation of vitamin D by alumina column chromatography and freeze crystallization 3 , can be separated to obtain products with higher purity, which has certain application value, but at the same time, there are shortcomings such as small processing capacity, low recovery rate, large solvent consumption, and difficulty in reusing the adsorbent.

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