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Medical devices with lubricious surfaces when wet

A medical appliance and lubricity technology, applied in the field of medical appliances, can solve the problem of high risk of surface lubricating layer peeling off

Active Publication Date: 2011-11-30
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, in the case where the substrate polymer is difficult to be swollen by the hydrophilic polymer solution, the hydrophilic polymer forming the surface lubricating layer is fixed on the substrate only by the effect of insolubility, and forms an interpenetrating network. Higher risk of peeling of the lubricating layer on the surface compared to structured polymer substrates

Method used

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  • Medical devices with lubricious surfaces when wet
  • Medical devices with lubricious surfaces when wet
  • Medical devices with lubricious surfaces when wet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0065]As a specific embodiment of fixing the thiol compound 2 on the substrate layer 1, the following embodiments can be enumerated: (i) before the solution of the compound having a thiol group is applied to the surface of the substrate layer, the The surface of the substrate layer is irradiated with ionized gas plasma, so that the compound having a thiol group is supported on the substrate layer. Specifically, it is an embodiment in which the surface of the substrate layer 1 is plasma-treated before the solution (thiol compound solution) in which the thiol compound is dissolved is applied on the surface of the substrate layer 1 (before the coating of the thiol compound). body treatment to modify and activate the surface, and then apply the thiol compound solution to react (bond / immobilize) the thiol compound 2 with the surface of the substrate layer 1 . In this embodiment, the thiol compound 2 can be firmly fixed on the surface of the substrate layer 1 . That is, generally, ...

Embodiment 1

[0153] [Example 1] Substrate: Nylon 12

[0154] A thin sheet (length 30 mm x width 50 mm x thickness 1 mm; polymer substrate layer 1) of nylon 12 (Grillamid L 16, manufactured by EMS) was ultrasonically cleaned in acetone, and then a nozzle with a width of 1 inch was installed on the plasma irradiation surface. On the device (DURADYNE, PT-2000P, manufactured by TRI-STAR TECHNOLOGIES), under the conditions of atmospheric pressure, air flow: 15SCFH, plasma current: 2.00A, argon is irradiated from a distance of 10mm to the entire surface of the nylon 12 sheet for 25 seconds Ion plasma (plasma treatment prior to coating of thiol compounds).

[0155] The nylon 12 sheet subjected to the plasma treatment before coating with the above-mentioned thiol compound was immersed in tris-[(3-mercaptopropionyloxy)-ethyl]isocyanurate (TEMPIC) adjusted to a concentration of 20 mM ( (manufactured by SC Organic Chemicals Co., Ltd.) (3 thiol groups per molecule) in DMF solution, after 10 minutes o...

Embodiment 2

[0173] [Example 2] base material: LDPE

[0174] A thin sheet (long 30mm * wide 50mm * thickness 1mm; polymer substrate layer 1) of low density polyethylene (LDPE) (NOVATEC LD LC720, manufactured by Japan Polyethylene Corporation) is carried out ultrasonic cleaning in acetone, then use and embodiment 1 Argon ion gas plasma irradiation (plasma treatment before thiol compound coating) was performed for 25 seconds under the same conditions as in Example 1 using the same plasma irradiation apparatus.

[0175] The LDPE sheet subjected to the plasma treatment before the application of the above-mentioned thiol compound was immersed in a THF solution of TEMPIC adjusted to a concentration of 20 mM, dried naturally for 3 minutes, and then again under the above-mentioned conditions using the above-mentioned plasma irradiation device. Argon ion gas plasma irradiation for 25 seconds (plasma treatment after thiol compound coating). Then, the TEMPIC was immobilized on the surface of the LDP...

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Abstract

Provided is a medical device wherein a surface lubricating layer and one of various polymer bases are fixed with each other firmly by a simpler technique. The medical device permanently exhibits excellent surface lubricity when in use. Specifically disclosed is a medical device (10) which has a lubricating surface when wet. The medical device (10) is characterized by comprising a base layer (1) at least the surface of which is composed of a polymer material, a compound (thiol compound) (2) which is supported by at least a part of the base layer (1) and has a plurality of thiol groups in each molecule, and a surface lubricating layer (3) which covers the thiol compound (2) and is composed of a hydrophilic polymer that has a reactive functional group. The medical device (10) is also characterized in that the thiol compound (2) is supported by (fixed to) the base layer (1) by irradiation of ionized gas plasma, and that the surface lubricating layer (3) is bonded to the base layer (1) by reacting the thiol compound (2) with the hydrophilic polymer that has a reactive functional group.

Description

technical field [0001] The present invention relates to medical devices having lubricious surfaces when wet. Background technique [0002] Medical instruments such as catheters, guide wires, and indwelling needles that are inserted into living bodies are required to exhibit excellent lubricity in order to reduce tissue damage to blood vessels and the like and improve operator operability. Therefore, a method of coating the surface of a substrate with a lubricating hydrophilic polymer has been developed and put into practical use. In such a medical device, the hydrophilic polymer is eluted and peeled off from the surface of the base material, which poses problems from the viewpoints of safety, maintainability of handling, and the like. [0003] In order to prevent this problem, Japanese Patent Application Laid-Open No. 8-33704 discloses a medical device in which a water-soluble or water-swellable polymer is dissolved in a solvent that swells the base material of the medical ...

Claims

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Application Information

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IPC IPC(8): A61L29/00A61L31/00
CPCA61L31/14A61L2400/18A61L29/14Y10T428/261Y10T428/265Y10T428/31504Y10T428/31536A61L27/14A61L27/28A61L29/04A61L29/08A61L29/085A61L2420/02A61L2420/06A61L2420/08
Inventor 小俣力也前田直之大西诚人
Owner TERUMO KK
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