Method for preparing carboxylic acid compound by promoting rapid hydrolysis of cyan

Abstract

The invention discloses a method for preparing a carboxylic acid compound by promoting rapid hydrolysis of cyan. Under the alkaline condition, cyan undergoes a hydrolysis reaction under the catalytic action of an iodine ion-containing compound, so that the carboxylic acid compound is generated. The method comprises the following steps of: 1) dissolving an alkaline compound or carbonate in water to obtain an alkaline solution; 2) adding an iodide into the alkaline solution, stirring for dissolving, and adding a cyan compound to perform a hydrolysis reaction; 3) cooling to the room temperature, adding sulfuric acid, and filtering after crystals are fully separated out to obtain a solid; 4) dissolving the solid in deionized water, and extracting with absolute ether; and 5) drying extract liquor, and removing diethyl ether by distilling to obtain the carboxylic acid compound. The invention has the advantages of simple process, low reaction temperature, reaction in the conventional heating device, easiness in implementing, short required reaction time, yield of up to 60 to 99 percent, and great improvement on production efficiency.

Description

technical field [0001] The invention relates to a method for promoting rapid hydrolysis of cyano groups to prepare carboxylic acid compounds, which belongs to the technical field of organic synthesis methods and chemical processes. Background technique [0002] The cyano group in the cyano (-CN) compound (organic matter is called nitrile) is a strong polar group, and the π bond is easily polarized. Most nitrile compounds are chemically synthesized, and some are produced by widely existing in nature. biosynthesis of (Acta Pharmaceutica Sinica, 2001, 28(6):76-81). Cyanide groups are often contained in many industrially valuable chemicals, and nitriles are usually used as starting materials for the synthesis of a series of amines, acids and polymers, and their hydrolysis reactions are widely used in amino acids, phthalamides, carboxylic acids and their derivatives Synthesis of compounds plays an extremely important role in organic synthesis. [0003] There have been many stud...

AI Technical Summary

Problems solved by technology

Amide derivatives can be prepared under metal ions and acid and alkali conditions, but when hydrolyzing carboxylic acids, the method of using low-concentration alkali or acid and adding metal ions is no longer applicable, the reaction conditions are more harsh, and the reaction is often incomplete. Mixture of amides and carboxylic acids (J. Mol. Catal. A: Chem. 2000, 160: 249; Bioorganic & Medicinal Chemistry, 2001, 9: 2993-2998)

Chinese invention patent 92104616.2 introduces a method of hydrolyzing hydroxynitrile with 60-98% concentrated sulfuric acid at 100-160°C, which requires a large amount of acid and takes a long time