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Application of thymopentin in intranasal vaccine

A vaccine and nasal drop technology, applied in the field of immunization, can solve the problems that major animal diseases cannot be effectively controlled and the protection rate is not high, and achieve the effect of protecting animal groups, wide variety range, and prolonging the level of antibody titer

Inactive Publication Date: 2011-06-08
NINGBO SANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the low protection rate of major animal diseases after immunization has become a worldwide problem, and it is also a key factor why major animal diseases cannot be effectively controlled worldwide.

Method used

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  • Application of thymopentin in intranasal vaccine
  • Application of thymopentin in intranasal vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] This example is a test of the intranasal vaccine to improve the immune response ability of porcine pseudorabies live vaccine

[0017] The existing intranasal vaccine adopts porcine pseudorabies live vaccine (K-61 strain, produced by Boehringer Ingelheim Animal Health (USA) Co., Ltd.).

[0018] Select 10 suckling pigs with the same breed, source and similar body weight, 5 pigs in the control group and 5 in the experimental group, immunized by intranasal vaccine,

[0019] Test group: Thymopentin was added to the special dilution liquid of porcine pseudorabies live vaccine at a dose of 2.0 mg / 100kg pig body weight, and then the live porcine pseudorabies vaccine was diluted. Each 2ml of the vaccine was taken as a portion, and the piglets were immunized by intranasal injection, with 1ml in each nostril.

[0020] Control group: the above-mentioned live porcine pseudorabies vaccine was diluted with a special dilution of porcine pseudorabies live vaccine, and thymopentin was n...

Embodiment 2

[0031] This example 2 is the test of thymopentin to improve the immune response ability of chicken Newcastle disease attenuated vaccine

[0032] The existing intranasal vaccine adopts the live chicken Newcastle disease low-virulence vaccine (La Sota strain, Nanjing Tianbang Biotechnology Co., Ltd.).

[0033] 10 1-day-old chicks of the same breed and source were selected and equally divided into the experimental group and the control group.

[0034] Test group: according to the dose of thymopentin 2.5 μg / feather (about 125 grams). Dissolve 2.5 mg of thymopentin in 1 ml of physiological saline and add it to 50 ml (1000 parts) of the vaccine, and shake well. Then, 1 drop (0.05 ml, 1 bird) was instilled in the nose of each chicken, and the 5 chickens in this group were immunized.

[0035] Control group: add 1ml of normal saline to 50ml (1000 parts) of the vaccine and shake well. Then, 1 drop (0.05 ml, 1 bird) was instilled in the nose of each chicken, and the 5 chickens in this...

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Abstract

The invention relates to an application of thymopentin in an intranasal vaccine, which is characterized in that the thymopentin is added in the existing intranasal vaccine as an adjuvant for improving immune response capability of an animal to the exiting intranasal vaccine. Compared with the prior art, the thymopentin is adopted as the immune adjuvant, thereby being capable of greatly improving antibody titer generated after the animal is immunized with the intranasal vaccine and also prolonging high antibody titer level generated after the animal is immunized with the vaccine; the range of animal objects using the immunization and the range of varieties of the intranasal vaccines are wide; and immunization can be completed by one-time injection after being compatible with the intranasal vaccine, and the using method is simple. Even in regions where highly pathogenic blue ear disease, circovirus, newcastle disease, duck plague and other epidemic diseases capable of damaging immune systems of animal bodies are endemic, the nationally stipulated standard can be achieved after the use of the immunization, the protection rate of a colony can be above 70%, and the animal colony can be effectively protected.

Description

technical field [0001] The invention relates to the field of immunization, in particular to the application of thymopentin in a nasal drop vaccine and a method of using the same. Background technique [0002] In today's increasingly developed aquaculture industry, the use of vaccines has become an indispensable guarantee for the success of the industry. The main role of vaccines is to prevent infectious diseases. The so-called vaccine is a product made of pathogenic microorganisms with better immunogenicity after reproduction and treatment. After inoculation into the animal body, it stimulates the body to produce specific antibodies. When the antibody in the body reaches a certain value, it can resist the pathogen. Invasion and infection of microorganisms, thus playing a role in preventing this disease. Vaccination methods mainly include injection, nasal drip, eye instillation, drinking water, oral administration, spray and so on. [0003] In livestock production, especia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P37/02
CPCY02A50/30
Inventor 孙泽祥翁士乔王伟国崔贞亮孙鹏烈朱顺娣李俊婷何来君黄峰年孙慕懿
Owner NINGBO SANSHENG PHARMA
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