Method for preparing marine plant alginate polysaccharide enteric coated hard capsules

Abstract

The invention provides a method for preparing marine plant alginate polysaccharide enteric coated hard capsules. The method is characterized by comprising the following steps of: weighing sodium alginate, adding deionized water for stirring and dissolving the sodium alginate to prepare hydrosol with concentration of between 0.1 and 30% by mass percentage; adding glycerol with purity of more than 96% to ensure the concentration of the glycerol is between 0.1 and 10% by mass percentage; uniformly stirring, and defoaming; immersing die rods of capsule dies of between No.0 to 5 into the defoamed glycerol for 4 to 15 seconds; picking up the die rods, turning over the die rods for 3 to 5 times, and coagulating the die rods in a coagulating bath; drying under a constant-temperature constant humidity condition, and pulling out casings to prepare the alginate polysaccharide enteric coated hard capsules. The marine plant alginate polysaccharide enteric coated hard capsules prepared by the method have the advantages of excellent membrane forming property, sustained release property, safety, stability, biocompatibility, biodegradability and the like; and the quality and safety of the capsules are improved.

Description

technical field [0001] The invention relates to a preparation method of a marine plant hollow capsule, in particular to a preparation method of a marine plant fucoidan enteric-coated hard capsule. Background technique [0002] Capsules are often used to fill medicines and health foods. They have a bright appearance, can mask the peculiar smell of medicines, are easy to swallow, and are easy for consumers to accept. The bioavailability of functional factors is high, the amount of excipients is small, and they disintegrate quickly in the gastrointestinal tract , generally 3-10 minutes after taking it, it can disintegrate and release functional substances; compared with pills and tablets, capsules have the advantages of quick effect, good absorption, good stability, and long shelf life, so they are very popular among consumers. [0003] Most of the existing hollow hard capsules use animal gelatin as the wall material. Gelatin is produced from animal leather scraps. These scrap...

AI Technical Summary

Problems solved by technology

However, in view of the harmful chemical components contained in it, there are strict limit requirements for use in medicines. The Chinese Pharmacopoeia's paraben (paraben) preservatives have a maximum limit of 0.05% in medicines, while in Japan, It has been banned from human consumption. Another potential safety hazard of gelatin capsules is the sterilization process of capsule ethylene oxide. Due to the carcinogenic effect of ethylene oxide, it is prohibited to be used for drug sterilization in Europe, America and other regions. The quality and safety of hollow capsules The industry even vividly said that "taking capsule preparations is not taking medicine, but taking poison". However, this problem has been ignored by the "outsider" people, and it has become a pain that the Chinese pharmaceutical industry should not bear.

China is a big exporter of preparations, but every year some products in the form of capsules are lost in many markets because the safety indicators of the capsules do not meet the requirements of the importing country. There is serious resistance to preparations in Islamic countries and regions and vegetarians. Therefore, people have been working hard to improve the quality of capsule shells and find a new type of capsule raw material with safer quality, abundant resources, and low price.