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Medicinal composition for treating ulcerative colitis and preparation method thereof

A drug and colon positioning technology, which is applied in drug combinations, pharmaceutical formulas, medical preparations with non-active ingredients, etc., can solve the problems of complex raw materials and components, and achieve the effects of convenient use, recurrence prevention, and improvement of diarrhea

Inactive Publication Date: 2014-02-05
杨明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, in the existing preparations, the effective components of Radix Astragali and Sophora flavescens are all administered in the colon. Due to the complexity of raw materials, whether this form of administration can achieve the best drug effect is a question for those skilled in the art. is unpredictable

Method used

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  • Medicinal composition for treating ulcerative colitis and preparation method thereof
  • Medicinal composition for treating ulcerative colitis and preparation method thereof
  • Medicinal composition for treating ulcerative colitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 medicine of the present invention

[0038] 1. Preparation of Astragalus gastric drug-releasing unit:

[0039] Take 2.5g of astragaloside extract, 7.5g of astragalus polysaccharide extract, 18g of microcrystalline cellulose, 3.5g of micropowder silica gel, 2g of sodium carboxymethyl starch, powdered and mixed evenly through No. 6 sieve (100 mesh, 150 μm) A soft material is prepared with an appropriate amount of 50% ethanol as a wetting agent, extruded and spheronized to obtain pellets. Adopt Eudragit E100 alcohol-soluble coating, and its coating prescription is Eudragit E100 10g; Talcum powder 5g; PEG6000 1g; Water 2g; Ethanol 140g. Dissolve Eudragit E100 in about 70g of ethanol; dissolve PEG6000 in water; add talc powder to the remaining ethanol and homogenize at high speed for 20 minutes; add PEG6000 solution and talc powder suspension into Eudragit E100 solution, stir well to obtain the coating liquid. Adopt the fluidized bed coating t...

Embodiment 2

[0050] The preparation of embodiment 2 medicines of the present invention

[0051] 1. Prescription of gastric release unit preparation

[0052] Astragalus coated pellets

[0053] Astragalus polysaccharide extract 398mg (containing polysaccharide 355mg) Astragalus saponin extract 136mg (containing saponin 100mg)

[0054] Microcrystalline cellulose 961mg Micropowder silica gel 187mg

[0055] Carboxymethyl Starch Sodium 107mg Coating 90mg

[0056] Total 1879mg

[0057] 2. Prescription of colon-localized drug release unit preparation

[0058] 2.1pH-sensitive single-layer coated pellets

[0059] Matrine Extract 51mg (Matrine 50mg) Oxymatrine Extract 153mg (Oxymatrine 150mg)

[0060] Microcrystalline Cellulose 755mg Sodium Carboxymethyl Starch 61mg

[0061] Coating 306mg

[0062] Total 1326mg

[0063] 2.2 pH-sensitive double-layer coated pellets

[0064] Matrine Extract 51mg Oxymatrine Extract 153mg

[0065] Microcrystalline Cellulose 755mg Sodium Carboxymethyl...

Embodiment 3

[0074] Embodiment 3 The screening test of pharmaceutical adjuvant of the present invention and preparation technology

[0075] One, the preparation of drug stomach-colon release capsule of the present invention

[0076] The medicine of the present invention is divided into two parts, wherein astragaloside and polysaccharide are prepared into preparation units capable of rapid drug release in the stomach, matrine and oxymatrine are prepared into preparation units with colon-localized drug release performance, and then The two preparation units are mixed and assembled into a compound drug delivery system including two kinds of drug release behaviors.

[0077] See the specific process route figure 1 .

[0078] 1 Instruments and reagents:

[0079] 1.1 Instrument

[0080] Spherical pellet granulator (Institute of Chemical Machinery, East China University of Science and Technology)

[0081] Friability monitor (FT-2000, Tianjin Sixin Technology Co., Ltd.)

[0082] Powder flowab...

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Abstract

The invention provides application of a gastric medicament release system prepared from astragalus or active ingredients thereof and a colon positioning medicament release system prepared from lightyellow sophora root or active ingredients thereof in the preparation of combined medicaments for treating ulcerative colitis, and also provides a medicinal composition for treating the ulcerative colitis, which is a preparation prepared by mixing the gastric medicament release system prepared from the astragalus or active ingredients thereof and the colon positioning medicament release system prepared from the lightyellow sophora root or active ingredients thereof. Through the comparative experimental study of medicinal effect of different administration modes of each component, compared with two preparation modes of total formula colon administration and total formula oral administration, a preparation prepared by combining the oral administration of astragalus polysaccharide and saponin with the enteroclysis of matrine and oxymatrine can resist rat colon tissue pathological injury caused by trinitro-benzene-sulfonic acid obviously, improve apparent physical signs such as hematochezia, diarrhoea, anorexia, indolence and the like of animals and play a role by regulating the peripheral blood TNF-alpha level and inflammatory reactions in colon tissue, has obvious curative effect and can both regulate the integral immunologic function and resist the local inflammatory reactions in colon.

Description

technical field [0001] The invention relates to the use of a gastric drug delivery system prepared from astragalus or its active ingredients and a colon-localized drug delivery system prepared from flavescens or its active ingredients in the preparation of combined drugs for treating ulcerative colitis. Background technique [0002] Ulcerative colitis is a primary, non-specific chronic disease of the colon. Colonoscopy shows that only the mucosa and submucosa of the colon are invaded, and there are erosions and superficial ulcers. At present, astragalus and flavescens are combined to treat ulcerative colitis, and there are related patents or literature reports, such as: patent application number: 200410040960.7, invention name: a pharmaceutical composition for treating ulcerative colitis, its preparation method and use , the patent application discloses a pharmaceutical composition for treating ulcerative colitis, which contains medicaments prepared from astragalus and flave...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K47/38A61K9/16A61P1/04
Inventor 杨明谢兴亮韩丽曾敏顾原晓
Owner 杨明
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