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Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection

A technology of amoxicillin sodium flucloxacillin sodium and its composition is applied in the direction of liposome delivery, active ingredients of heterocyclic compounds, antibacterial drugs, etc., and can solve the problem of protection, Poor product stability, affecting clinical efficacy and other issues, to achieve the effect of improving drug therapeutic index, high stability, and reducing drug side effects

Inactive Publication Date: 2012-09-26
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method simply mixes and subpackages the two, and does not protect the active ingredients amoxicillin sodium and flucloxacillin sodium accordingly, resulting in poor product stability and seriously affecting the clinical efficacy

Method used

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  • Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection
  • Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection
  • Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Amoxicillin Sodium Flucloxacillin Sodium Pharmaceutical Composition Liposomal Injection

[0027] Prescription (specification 0.5g)

[0028] Amoxicillin Sodium 25g

[0029] Flucloxacillin Sodium 25g

[0030] Soy Lecithin 100g

[0031] Cholesterol 20g

[0032] Glucose 62.5g

[0033] Mannitol 62.5g

[0034] Sodium Benzoate 2.5g

[0035] making process

[0036] (1) 100g soybean lecithin and 20g cholesterol are dissolved in the mixed solvent of 3: 1 isopropanol and ethanol in 800ml volume ratio, place the organic solvent under reduced pressure on the rotary thin film evaporator, obtained phospholipid film, add 500ml of citric acid-sodium citrate buffer solution with a pH value of 5.6 was stirred and dissolved to obtain a blank liposome solution;

[0037] (2) Dissolve 25g of amoxicillin sodium and 25g of flucloxacillin sodium in 300ml of water for injection, mix evenly with the prepared blank liposome solution, heat it at 70°C for 40 minutes, ...

Embodiment 2

[0039] Example 2 Preparation of Amoxicillin Sodium Flucloxacillin Sodium Pharmaceutical Composition Liposome Injection

[0040] Prescription (specification 1.0g)

[0041] Amoxicillin Sodium 50g

[0042] Flucloxacillin Sodium 50g

[0043] Soy Lecithin 300g

[0044] Cholesterol 75g

[0045] Glucose 250g

[0046] Mannitol 250g

[0047] Sodium Benzoate 35g

[0048] making process

[0049] (1) 300g soybean lecithin and 75g cholesterol are dissolved in the mixed solvent of 3: 1 isopropanol and ethanol in 1500ml volume ratio, place the organic solvent under reduced pressure on the rotary thin film evaporator, obtained phospholipid film, add 800ml of citric acid-sodium citrate buffer solution with a pH value of 5.6 was stirred and dissolved to obtain a blank liposome solution;

[0050] (2) Dissolve 50g of amoxicillin sodium and 50g of flucloxacillin sodium in 500ml of water for injection, mix evenly with the prepared blank liposome solution, insulate at 50°C for ultrasonic treat...

Embodiment 3

[0052] Example 3 Preparation of Amoxicillin Sodium Flucloxacillin Sodium Pharmaceutical Composition Liposome Injection

[0053] Prescription (specification 2.0g)

[0054] Amoxicillin Sodium 100g

[0055] Flucloxacillin Sodium 100g

[0056] Soy Lecithin 500g

[0057] Cholesterol 120g

[0058] Glucose 350g

[0059] Mannitol 350g

[0060] Sodium Benzoate 30g

[0061] The preparation process was the same as in Example 2, and the liposome injection of the amoxicillin sodium flucloxacillin sodium pharmaceutical composition was prepared.

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Abstract

The invention provides an amoxicillin sodium flucloxacillin sodium medicine compound liposome injection which comprises amoxicillin sodium, flucloxacillin sodium, liposome carrier, lyoprotectant and optionally existing preservative, wherein the liposome carrier is soy lecithin and cholesterol. The liposome injection has good preparation stability, the liposome during freeze drying process does not crack caused by dehydration, fusion, ice crystal formation and the like; and likewise, the liposome keeps good encapsulation efficiency after hydration redissolution.

Description

technical field [0001] The invention relates to an antibiotic liposome preparation, in particular to an amoxicillin sodium flucloxacillin sodium pharmaceutical composition liposome injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Amoxicillin sodium and flucloxacillin sodium are compound antibiotics composed in a ratio of 1:1. Amoxicillin is a semi-synthetic broad-spectrum penicillin, which belongs to the aminopenicillin class. It has bactericidal effect on both Gram-negative and positive bacteria. It is characterized by broad-spectrum and penicillinase resistance. Flucloxacillin is a semi-synthetic isoxazole penicillin, which is not easily destroyed by penicillinase, and has a bactericidal effect on penicillinase-producing drug-resistant Staphylococcus aureus. Mainly used for penicillin-resistant Staphylococcus infection, but Gram-negative bacteria are resistant to flucloxacillin. The antibacterial mech...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/431A61K31/43A61K9/14A61K9/127A61P31/04
Inventor 杨明贵
Owner HAINAN MEILAN SMITH KLINE PHARMA
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