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Palladium-103 and io-125 compound sealed seed source, source core and source core preparation method

A compound sealing and seed source technology, which is applied in the directions of radiotherapy, drug combination, antineoplastic drugs, etc., can solve the problem that there is no palladium-103 composite seed source, it is difficult to deposit iodine-125, and the chemical properties are very different and other problems, to achieve the effect of short reaction time, good therapeutic effect and uniform distribution

Active Publication Date: 2010-08-11
HTA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are certain difficulties in simultaneously plating palladium-103 and iodine-125 on the carrier. If palladium-103 and iodine-125 are deposited on the carrier at the same time, the deposition of palladium-103 requires A reducing agent is used, and the deposition of iodine-125 requires an oxidant, and the two cannot exist in the same solution at the same time; if palladium-103 is plated on the carrier first, it is difficult to deposit iodine-125 on it due to the stable chemical properties of palladium; If iodine-125 is plated first, iodine-125 is deposited in the form of AgI, due to the presence of NH during electroless palladium plating 4 OH, will cause a large loss of AgI
Based on the above reasons, the researches reported so far are limited to implanting palladium-103 seed source and iodine-125 seed source into tumor tissue respectively, and there is no seed source that combines palladium-103 and iodine-125

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The present embodiment is the most preferred technical scheme, and the reagents used are all analytically pure.

[0045] A source core of palladium-103 and iodine-125 composite sealed seed source, with a metal or non-metal that can be used as an X-ray marker as a carrier, and a layer of radioactive isotope film is covered on the carrier, the key lies in: the radioisotope The film is a composite film of palladium-103 and iodine-125. The metal carrier is made of one of silver, copper, nickel, palladium, gold or an alloy containing the metal, the non-metallic carrier is made of resin, plastic, etc., and the carrier in this embodiment is made of silver . The shape of the carrier can be rod or pellet, and the carrier in this embodiment is made into a rod. The specification of the carrier rod is 0.1-2.0 mm in diameter and 1.0-10.0 mm in length. In this embodiment, a silver rod with a diameter of 0.5 mm and a length of 3 mm is preferably used as the carrier.

[0046] A com...

Embodiment 2

[0059] Other contents remain unchanged, and the difference from Embodiment 1 is:

[0060] A method for preparing the above-mentioned palladium-103 and iodine-125 composite sealed seed source source core, comprising the steps of:

[0061] (1) Inoculation of nano-palladium seed crystals:

[0062] (a) immerse the silver rod in the chloroform solution of 0.1mol / L palladium acetate for 20 minutes, blow dry with air after taking it out, wherein the palladium acetate can be replaced with palladium nitrate or palladium acetylacetonate of the same concentration;

[0063] (b) Immerse the silver rod in the alkaline ammonia solution of hydrazine for 20 minutes. The concentration of hydrazine in this solution is 0.5mol / L, and the concentration of ammonia is 0.1mol / L. After taking it out, dry it at a temperature of 80°C;

[0064] (c) Steps (a) and (b) are repeated 10 times, so that the surface of the silver rod is covered with a layer of nano-palladium seed crystals.

[0065] (2) Electrol...

Embodiment 3

[0068] Other contents remain unchanged, and the difference from Embodiment 1 is:

[0069] A method for preparing the above-mentioned palladium-103 and iodine-125 composite sealed seed source source core, comprising the steps of:

[0070] (1) Inoculation of nano-palladium seed crystals:

[0071] (a) silver rod is immersed in the chloroform solution of 5mol / L palladium acetate for 3 minutes, blow dry with air after taking out, wherein palladium acetate can be replaced with palladium nitrate or palladium acetylacetonate of the same concentration;

[0072] (b) Immerse the silver rod in the alkaline ammonia solution of hydrazine for 3 minutes, the concentration of hydrazine in this solution is 10mol / L, the concentration of ammonia is 5mol / L, and dry at a temperature of 160°C after taking it out;

[0073] (c) Repeat steps (a) and (b) for 3 times, so that the surface of the silver rod is covered with a layer of nano-palladium seed crystals.

[0074] (2) Electroless plating of palla...

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Abstract

The invention belongs to the technical field of medical preparations containing radioactive substances, in particular to a palladium-103 and io-125 compound sealed seed source, a source core and a source core preparation method. A palladium-103 and io-125 compound film covers on a carrier to form the source core, and the palladium-103 and io-125 compound sealed seed source is prepared in a way that the source core is welded and sealed in a titanium pipe or titanium alloy pipe. The source core preparation method of the palladium-103 and io-125 compound sealed seed source comprises the steps of: 1, inoculating a nano palladium seed crystal: dipping a carrier bar into a chloroform solution of palladium diacetate, and then dipping into an alkaline ammonia solution of hydrazine; 2, carrying out chemical plating on palladium-103 and silver: putting the carrier bar into a mixed solution of palladium chloride, silver nitrate, ethylene diamine tetraacetic acid, ammonium hydroxide and hydrazine to enable the surface of a carrier to be uniformly coated with a layer of palladium-103 and silver; and 3, carrying out chemical absorption of iodine-125: putting the carrier bar into a mixed solution of sodium bromide or potassium bromide, sodium iodide or potassium iodide, sodium hydroxide or potassium hydroxide, and potassium ferricyanide.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing radioactive substances, and in particular relates to a palladium-103 and iodine-125 composite sealed seed source, source core and source core preparation method. Background technique [0002] Interstitial implantation therapy is to implant radioactive seeds into tumor tissue, and use the rays emitted by the seeds to kill and kill tumor cells, so as to treat tumors and alleviate diseases. Interstitial implantation therapy has been used in the treatment of various solid tumors, such as prostate cancer, breast cancer, liver cancer, lung cancer, brain cancer, ovarian cancer, etc., and achieved the same or even better therapeutic effect than surgery and external radiation therapy. Interstitial implantation therapy is divided into temporary implantation and permanent implantation. Temporary implantation refers to implanting radioactive seeds into the tumor site and taking them ou...

Claims

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Application Information

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IPC IPC(8): A61K51/02A61P35/00A61M36/00A61K101/02
Inventor 高惠波李忠勇张文辉韩连革尹卫陈大明刘卓王巍邓雪松金小海
Owner HTA CO LTD
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