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Compound radix salviae miltiorrhizae film slow-release tablet and preparation method thereof

The technology of compound salvia and sustained-release tablets is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of short distribution half-life and elimination half-life, many times of taking, and unsustainable curative effect, etc. The effect of mild intestinal irritation, prolonged drug efficacy, and improved bioavailability

Inactive Publication Date: 2013-03-20
GUANGDONG PHARMA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are disadvantages such as many times of taking (3 times a day) and a slightly large amount (3 tablets each time) and other disadvantages
In addition, according to recent literature reports, salvianolic acid B is the most important component of Salvia miltiorrhiza in the compound Danshen Tablets for the treatment of cardiovascular diseases. 1.48h, after continuous administration, the drug does not accumulate in the body, and the drug is basically eliminated from the body within 12 hours, and the curative effect cannot last

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Extract 4.5 kg of Salvia Miltiorrhiza in three times, add 95% ethanol to reflux for 1.5 hours for the first time, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.30 (55-60°C); add 50% ethanol for 1.5 hours to reflux for the second time, filter Add water for the third time and reflux for 2 hours, filter, concentrate to a relative density of 1.40 (55-60°C), combine with the first concentrated solution, and mix to make a relative density of 1.35-1.39 (55°C). Danshen Qing Ointment.

[0039] Grind 1.4kg Panax notoginseng into fine powder, pass through 80-mesh sieve, mix well with salvia miltiorrhiza clear paste, dry under reduced pressure in a vacuum drying oven, and powder through 80-mesh sieve. Recover ethanol from the second extract, dilute it with water, pass it through a macroporous resin column, concentrate to a relative density of 1.40 (55-60°C), and dry it under reduced pressure in a vacuum oven; 80 mesh sieve), mixed evenly, and gr...

Embodiment 2

[0043] 4.2 kg of Salvia Miltiorrhiza was extracted three times. For the first time, add 95% ethanol to reflux for 1.5 hours, filter, recover ethanol from the filtrate, and concentrate to a relative density of 1.30 (55-60°C); for the second time, add 50% ethanol to reflux for 1.5 hours, filter Add water for the third time and reflux for 2 hours, filter, concentrate to a relative density of 1.40 (55-60°C), combine with the first concentrated solution, and mix to make a relative density of 1.35-1.39 (55°C). Danshen Qing Ointment.

[0044] Crush 1.41kg of notoginseng into fine powder, pass through a 80-mesh sieve, mix well with salvia miltiorrhiza clear paste, dry under reduced pressure in a vacuum drying oven, and powder through an 80-mesh sieve. Recover ethanol from the second extract, dilute it with water, pass it through a macroporous resin column, concentrate to a relative density of 1.40 (55-60°C), and dry it under reduced pressure in a vacuum oven; 80 mesh sieve), mixed ev...

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Abstract

The invention discloses a compound radix salviae miltiorrhizae film slow-release tablet and a preparation method thereof. The compound radix salviae miltiorrhizae film slow-release tablet comprises a tablet core and coating liquid, wherein, the tablet core mainly comprises the following components by weight percent: 67.5% to 82.5% of radix salviae miltiorrhizae extract, 8.5% to 22% of red phenolic acid B, 8% to 22% of radix notoginseng, 0.10% to 0.15% of borneol and the balance of auxiliary materials; the coating liquid comprises the following components by weight percent: 1.0% to 5.0% of ethyl cellulose, 3.5% to 8.5% of lactose, 0.3% to 0.8% of dibutyl phthalate and the balance of ethanol water solutions. The invention adopts a peculiar formula and a preparation technique, the slow-release preparation obtained by preparation enhances the content of the effective component of the red phenolic acid B of the medicine, the content of the red phenolic acid B in each composition of single dose is more than 50%, the release of the medicine is controlled by a film slow-release technology, the bioavailability is enhanced, the curative effect of the medicine is prolonged, the drug administration frequency is reduced, and the invention has the advantages of small fluctuation of apex and vale blood concentration, light stimulation reaction of gastrointestinal tracts, lasting and safe curative effect and the like.

Description

technical field [0001] The invention relates to a compound salvia miltiorrhiza sustained-release tablet. Background technique [0002] Compound Salvia Miltiorrhiza is a modern prescription. The drug prescription is composed of Salvia Miltiorrhiza Extract, Panax notoginseng, and Borneol. Danshen promotes blood circulation and relieves pain, Panax notoginseng promotes blood circulation and invigorates qi, and borneol guides the sutras and assists each other. They complement each other and have a good multi-target effect on cardiovascular diseases, such as strengthening the heart, promoting blood circulation, regulating fat, lowering blood pressure, and relieving pain. It is the crown of clinical treatment. Commonly used traditional Chinese medicine prescriptions for heart disease, chest tightness, and angina pectoris. "Chinese Pharmacopoeia" 1985 edition, 1995 edition, 2000 edition and 2005 edition are all collected. But there are disadvantages of inconvenience such as many ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K36/537A61K36/258A61K31/045A61K31/343A61P9/10
Inventor 谭载友曾胜张浩朱尔佳叶婉兰梁召麟
Owner GUANGDONG PHARMA UNIV
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