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Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same

A thermoplastic elastomer and bottle stopper technology, which is applied in the direction of medical containers, pharmaceutical packaging, and packaging items, can solve problems such as pollution, high energy consumption in production, waste of resources and the environment, and achieve shortening of the process flow, improvement of production efficiency, chemical stable effect

Inactive Publication Date: 2012-08-08
谷其昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (2) Since the surface of the medicinal halogenated butyl rubber cork forms a very fragile and incomplete molecular rubber film, it cannot completely wrap the filling and reinforcing agent in the rubber compounding system, and it is easy to wear and tear. It is easy to release insoluble substances such as calcium carbonate, kaolin, titanium dioxide and other reinforcing fillers, which will cause visible foreign matter and insoluble particles in injection medicines, especially infusion medicines, to exceed the standard, thus affecting the quality of medicines and medication safety
[0009] (3) Use inert polymer materials such as Teflon (TEFULO) on the surface of pharmaceutical halobutyl rubber stoppers to make film-coated (coated) rubber stoppers to solve the above problems (1) and (2) , will increase the manufacturing cost of medicinal bottle stoppers. At the same time, because the polymer film is hard and not tightly sealed with the container, it is easy to cause problems such as leakage of the packaging liquid and bacterial contamination.
[0011] (5) Medical halogenated butyl rubber stoppers are prone to acupuncture and chipping during the clinical medication process, causing medication safety problems
[0012] (6) Since halogenated butyl rubber is a polar polymer and has adhesiveness, the medicinal halogenated butyl rubber stopper is easy to absorb dust and fibers, which affects the quality of medicines
[0013] (7) Pharmaceutical halogenated butyl rubber is a thermosetting elastomer, and the scraps and defective products in the manufacturing process cannot be recycled and reused; pharmaceutical halogenated butyl rubber medical bottle stoppers are also disposable consumables. waste of resources and pollution of the environment
[0014] (8) The manufacture of medicinal halogenated butyl rubber medicinal bottle stoppers requires a long production process, strict production environment requirements, high factory construction costs, and high production energy consumption.

Method used

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  • Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same
  • Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same
  • Thermoplastic elastomer material, preparation thereof and method for manufacturing medicinal bottle stopper by using the same

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preparation example Construction

[0056] The preparation method of the thermoplastic elastomer material that the embodiment of the present invention provides, comprises the following steps:

[0057] (1) At a temperature of 80-100°C, after 1-3 hours, dry the material until the moisture content is no more than 0.1% of its total weight, wherein the material includes 350-350% of the styrene-based copolymer or rubber-like material 500 parts, 100-450 parts of the polyolefin material, 200-500 parts of plasticizer and 50-150 parts of filler, 0-3 parts of compatibilizer, 0-1 part of antioxidant, 0-1 part of anti-oxidant Static agent, and 0 to 3 parts of anti-sticking agent.

[0058] (2) Put the dried material in step (1) into the reaction kettle, stir at 160-220°C for 1-1.5 hours, extrude it through a plastic extruder at 220-230°C, and cool it in the cooling water tank After being pulled by a tractor, it is cut into granules to obtain the thermoplastic elastomer material.

[0059] The barrel cleaning in the preparati...

Embodiment 1

[0073] By weight, select 500 parts of polystyrene-polyethylene-polybutylene-polystyrene polymer (SEBS), 100 parts of polypropylene (PP), 500 parts of white oil, 3 parts of triethylenetetramine, 150 parts Calcium powder, 1 part of tetrakis [β-(3,5-di-tert-butyl 4-hydroxy-phenyl) propionate] pentaerythritol ester, 3 parts of erucamide as materials for preparing thermoplastic elastomer materials, at a temperature of 90 ° C After 2 hours, dry the material until the moisture content is no more than 0.1% of its total weight; put the dried material into the reaction kettle, stir for 1 hour at 200°C to make it fused, and pass it through a plastic extruder at 225°C Extruding, after being cooled and shaped in the cooling water tank, it is drawn and cut into pellets by a tractor to obtain the thermoplastic elastomer material;

[0074] The barrel cleaning in the preparation method adopts polypropylene or polyethylene; the color masterbatch based on polypropylene or polyethylene is used. ...

Embodiment 2

[0076] By weight, select 400 parts of polystyrene-polyethylene-polybutylene-polystyrene polymer (SEBS), 200 parts of polypropylene (PP), 300 parts of white oil, 100 parts of calcium powder, 3 parts of erucamide , 1 part dodecyl-2-ol-propylamino-ethanol.

[0077] The preparation method is the same as in Example 1.

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Abstract

The invention provides thermoplastic elastomer materials used for a bottle cork for manufacturing medicines, a preparation method thereof and a method for applying the bottle cork for manufacturing medicines thereof. The materials are prepared by the following components: styrene copolymer or rubber materials as well as polyolefine matters. The styrene copolymer is PP or PE; besides, the materials also contain a plasticizer and a loading agent, contain or do not contain a compatibilizer, contain or do not contain an antioxidant, contain or do not contain an antistatic agent, contain or do notcontain adhesion preventives. The preparation method thereof includes the steps of drying the materials, fusing a reaction kettle, using a plastic extruding machine to extrude the materials, using a cooling water slot to cool and shape the materials, using a hauling machine to haul and cut off the materials, and the like. The thermoplastic elastomer materials provided by the invention have the advantages of stable chemical property, no poison, low polarity and good rebound resilience.

Description

technical field [0001] The invention relates to a thermoplastic elastomer material (TPE) for pharmaceutical bottle stoppers, a preparation method thereof and a method for using the same to manufacture medicinal bottle stoppers. Background technique [0002] Drugs have certain biological and chemical activities, and are special substances used by human beings for prevention, treatment, health care and reproduction. Ensuring the quality of medicines and ensuring the safety of medicines are important matters. For this reason, for the containers and materials of pharmaceutical packaging, especially the packaging medicinal corks of injection medicines directly used in the human body, it is necessary to use stable chemical properties, good sealing performance, direct contact with medicines, and stable quality of medicines. Elastomer materials used to make pharmaceutical stoppers for injection pharmaceutical packaging. [0003] In the past, natural rubber was used to make medicin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L25/08C08L23/16C08L9/02C08L23/22C08L23/28C08L47/00C08K5/20A61J1/14C08K5/00
Inventor 谷其昌
Owner 谷其昌
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