Ultra-fine dry powder particle suitable for drug administration for lung, and preparation method thereof

Abstract

The invention discloses a superfine drymeal granule suitable for pulmonary administration and a preparation method thereof. The drymeal granule has good air-atomizing property. With smaller geometric dimension, the drymeal granule can deposit in the alveolus area to maximum extent, so the active molecule of the medicine has higher bioavailability. In addition, the drymeal granule can be used for DNA and RNA lung administration. The invention is also designed to introduce how to use volatility salt to prepare the superfine drymeal granule with good air-atomizing property. The invention solves the technique defects of the over size of the drymeal granule, the low density of the granule, inconvenient application and easy inactivation of active drug ingredients caused by the sharp decline of the air-atomizing property resulting from the water absorbability in the lung superfine drymeal granule prepared by the existing drymeal preparation technique. Meanwhile, the invention also solves theproblem that the drymeal produced by the spray drying technology which is developed by Nektar Company, U.S.A, has relatively small deposition rate in the alveolus area and can not be used for transmitting protein, peptide or nucleic acid drugs containing DNA and RNA, and the like, caused by relatively small granule size and relatively high granule density.

Description

technical field [0001] The invention relates to the field of medicine preparation and delivery, in particular to an ultrafine dry powder particle suitable for pulmonary administration and a preparation method thereof. Background technique [0002] Inhalation drug therapy has a long history of use in the medical field. The earliest records of the application of drug therapy through the lungs can be traced back to thousands of years. Hippocrates in ancient Greece and Zhang Zhongjing in ancient China wrote in their works All mentioned the method that reaches the treatment disease by inhaling medicine. However, in the history of the development of medicine, the pulmonary drug delivery method is not the main drug delivery method, and the more commonly used drug delivery methods are still oral and injection. However, oral drugs and injections have their inherent defects. For example, oral drugs participate in the circulation of the body slowly, and it is difficult to reach the le...

AI Technical Summary

Problems solved by technology

Introducing how to utilize volatile salts to prepare fine dry powder particles with excellent aerosolization properties is another object of the present invention. Through the present invention, the existence of ultrafine dry powder particles in the lungs prepared by the existing AIR dry powder preparation technology is solved. The dry powder particle size is too large, the particle density is too small, it is inconvenient for practical application, and it is easy to absorb water and make its aerosolization properties drop sharply, resulting in the technical defect that the active ingredients of the drug are easily inactivated. The dry powder produced by the spray drying technology developed by the company, due to its high particle density, the small geometric size of the particles results in a relatively small deposition rate of the particles in the alveolar area, which cannot be used to deliver proteins, peptides and nucleic acids containing DNA and RNA. drug problem

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