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Beta carotene solid dispersion and prepraring method thereof

A technology of solid dispersion and β-carotene, which is applied in the direction of food preparation, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of low drug loading, poor water solubility, and incomplete miscibility of carriers, etc. problem, achieve good water solubility and water dispersibility, good stability, good coloring ability

Inactive Publication Date: 2008-10-29
沈阳皓天万嘉医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past literature patents, it mainly involves various methods for improving the stability of β-carotene and water dispersion, these methods mainly include microencapsulation method, cyclodextrin inclusion method, liposome, emulsion, emulsifier assistant Dissolution method, oil solution method, soft capsule method, etc. These methods may not be able to balance stability and water dispersibility, or the drug loading capacity is low, and organic solvents are required in the preparation, etc.
In Chinese patent CN03154152.6, the preparation method of lycopene dripping pills partly involves the content of solid dispersion, but because the inventor subjectively aims to prepare dripping pills, adding water-insoluble stearic acid and other ingredients into the formula, resulting in The product of this invention cannot be completely dissolved in water. In addition, the melting temperature of the preparation method is only 85°C, while the melting point of lycopene is as high as 170°C. It is not completely melted, and lycopene cannot be completely dispersed in the carrier in molecular form, and it is not completely miscible with the carrier. , did not completely form a water-soluble complex, and eventually its water solubility was poor

Method used

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  • Beta carotene solid dispersion and prepraring method thereof
  • Beta carotene solid dispersion and prepraring method thereof
  • Beta carotene solid dispersion and prepraring method thereof

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Embodiment 1

[0025] The lutein solid dispersion of the present invention is composed of the following raw materials by weight, lutein: polyethylene glycol: Tween 80=1:5:0.5.

[0026] Its preparation method is as follows: Take 10g of lutein and 50g of polyethylene glycol 4000 according to the above weight ratio, put them in a heating tank, heat up the oil bath to 170°C rapidly, cool down to 70-80°C rapidly, add Tween 80, Stir evenly, pour it on a stainless steel plate, pulverize it, pass through a 40-mesh sieve, and obtain it. The measured content of lutein is 9.2%.

Embodiment 2

[0028] The lutein solid dispersion of the present invention is composed of the following raw materials in weight ratio, zeaxanthin: polyethylene glycol 6000: ten polyglycerol oleate = 1:1:0.2.

[0029] The preparation method is as follows: take 100g of zeaxanthin and 6000100g of polyethylene glycol according to the above weight ratio, heat to 210°C and quickly cool down to 70-80°C, add 20g of decaglycerol oleate, stir evenly, pour it on a steel plate to cool , pulverized, and passed through a 40-mesh sieve to obtain a finished product with a measured content of 18%.

Embodiment 3

[0031] The astaxanthin solid dispersion of the present invention is prepared as follows: Take 10g of astaxanthin and 100g of polyethylene glycol 3350 type, add 2000ml of tert-butanol, heat to 70°C, dissolve, freeze-dry, and obtain the finished product. The content is 7%.

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Abstract

The invention discloses a solid dispersion of beta-carotene and the preparation method thereof. The beta-carotene comprises one of lycopene, lutein, zeaxanthin and astaxanthin or the random mixture of the materials, belonging to the fields of drugs and health care products. The solid dispersion of beta-carotene is composed of the following raw materials by preferred weight proportions: beta-carotene: polymer: additive equals to 1:3-10:0-5. The invention adopts a melting method and a solvent method to prepare the solid dispersion of beta-carotenen, which has good light and thermal stability and water-solubility or water dispersivity. The products can be prepared into tablets, capsules, pills, oral intake liquid and beverages.

Description

technical field [0001] The invention relates to a beta-carotene solid dispersion and a preparation method thereof, belonging to the field of medicines and health care products. Background technique [0002] β-carotene includes two types of compounds, one is carotene and lutein, carotene includes β-carotene and lycopene, lutein includes lutein, astaxanthin, and zeaxanthin. β-carotene widely exists in nature and is the color component of many organisms. Recent studies have found that β-carotene has important physiological functions for the human body. For example, β-carotene is the precursor of VA, which can be converted into VA in the human body. Lutein and zeaxanthin have unique physiological functions in protecting vision, preventing cardiovascular disease and cancer, and enhancing immunity. Lycopene and astaxanthin have strong antioxidant effects in preventing free radicals from invading biofilms, quenching singlet oxygen and capturing active oxygen free radicals. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/015A61K31/047A61K31/122A61K47/30A61K47/34A61K47/14A61K47/36A61K47/42A61K9/20A61K9/48A61P27/10A61P9/00A61P35/00C07C403/24A23L1/303A61K47/10A61K47/26A61K47/32
Inventor 董英杰艾莉
Owner 沈阳皓天万嘉医药科技有限公司
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