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Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof

A particle, thermal energy technology, applied in radiation therapy, X-ray/γ-ray/particle irradiation therapy, treatment, etc., can solve the problem of inability to cure cancer, achieve good chemical stability, biocompatibility, heat resistance, etc. The effect of excellent sex and sufficient blood supply

Inactive Publication Date: 2008-10-15
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this single hyperthermia treatment of cancer cannot further improve the cure rate of cancer.

Method used

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  • Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof
  • Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof
  • Microparticle with double function of radiotheraphy and thermotherapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Implementation Example 1. Use glass particles containing yttrium-89 nuclide and γ-Fe 2 o 3 Preparation of particles with dual functions of radiotherapy and thermotherapy and determination of their chemical stability:

[0042] Glass particles containing yttrium-89 nuclide with a particle size of 20-40 μm and γ-Fe 2 o 3 Powder mixing and grinding, in which the content of glass particles is 75%, γ-Fe 2 o 3 The powder content is 25% (mass percentage). Measure 10ml of phosphoric acid with a concentration of 85%, add 5ml of deionized water, and stir rapidly at 100°C; weigh 2.49g of Al 2 o 3 powder, slowly add H 3 PO 4 In the aqueous solution, continue stirring for about 15 minutes, until Al 2 o 3 Dissolved completely to obtain a white viscous aluminum phosphate polymer. Take 20g of glass particles and γ-Fe 2 o 3 The mixed powder is mixed with the prepared aluminum phosphate polymer, stirred at 100°C for 1-2 minutes, injected into a mold, and heat-treated at 500°C...

Embodiment 2

[0049] Implementation Example 2. Use glass microspheres containing phosphorus-32 nuclides and γ-Fe 2 o 3 Preparation of microspheres with dual functions of radiotherapy and thermotherapy and determination of their chemical stability:

[0050] With the ratio of 1 g glass microspheres: 100 ml NaOH solution, the glass microspheres containing phosphorus-31 nuclide were dispersed in 5 mol / L NaOH solution, and stirred with a magnetic stirrer for 48 hours. Subsequently, the microspheres were centrifuged from the NaOH solution, and the microspheres were washed three times with deionized water to completely remove the residual NaOH on the surface of the microspheres, and dried in an oven at 80 degrees for 12 hours. Take 2g of dried glass microspheres and disperse them in a mixed solution of 100ml ethanol and 40ml deionized water, add 0.11ml KH550, stir with a magnetic stirrer for 12 hours, wash the glass microspheres three times with ethanol and deionized water respectively, thoroughl...

Embodiment 3

[0058] Implementation example 3. Prepare particles with dual functions of radiotherapy and thermotherapy with glass particles containing yttrium-89 nuclide and manganese zinc ferrite with low Curie temperature and measure its hysteresis exothermic performance

[0059] Mix and grind glass particles containing yttrium-89 nuclide with a particle size of 20-40 μm and manganese-zinc ferrite powder according to a mass ratio of 1:1 to obtain uniformly mixed powder. Measure 10ml of phosphoric acid with a concentration of 85%, add 5ml of deionized water, and stir rapidly at 100°C; weigh 2.49g of Al 2 o 3 powder, slowly add H 3 PO 4 In the aqueous solution, continue stirring for about 15 minutes, until Al 2 o 3Dissolved completely to obtain a white viscous aluminum phosphate polymer. Take 20g of glass particles and γ-Fe 2 o 3 The mixed powder is mixed with the prepared aluminum phosphate polymer, stirred at 100°C for 1 to 2 minutes, injected into a mold, and heat-treated at 500°C...

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Abstract

The invention discloses particulates with double functions of internal radiotherapy and thermal therapy, and a preparation method thereof. The particulates are mainly compounded and formed by glass containing radioactive species yttrium-90 or / and phosphorus-32, and solid ferrite with magnetocaloric effect. When the particulates intervene in vivo, the radioactive species yttrium-90 or / and the phosphorus-32 contained in the glass can release Beta rays in vivo to kill cancer cells intervening in surrounding tissues without damaging the distant healthy tissues; the solid ferrite has good hysteresis exothermicity and can transform exosomatic magnetic energy into heat energy so as to release heat under the action of an external alternating magnetic field, so that the temperature around the tumor area can raise to 43 to 47 DEG C within a short time, and tumour cells intervening in the surrounding tissues are burnt and killed without influencing normal cells with better heat tolerance, thereby realizing the purpose of treating tumor by combining the internal radiotherapy and the thermotherapy, and having double lethality to cancer cells. The method for combining the radiation treatment and the heat treatment is an indispensable supplementary therapy means to treat the malignant tumor with chemical drug resistance. In addition, the particulates have good chemical stability and biocompatibility, and have great application prospect in the aspect of treating the malignant tumor.

Description

technical field [0001] The invention belongs to the field of biomaterials, and relates to microparticles with dual functions of internal radiation therapy and thermotherapy and a preparation method thereof. The mentioned particles can be used as a radiation source in the body to emit short-range and low-energy β-rays in the body to directly radiate cancer cells and kill cancer cells without damaging nearby normal tissue cells; Under the action of an alternating magnetic field, it becomes a heat source in the body and heats tumor cells, making the temperature of the tumor area reach 43-47°C, thereby killing cancer cells and leaving normal cells unaffected. Background technique [0002] Tumor is the biggest killer that threatens human life and health. According to the statistics of the World Health Organization, about 6.35 million people die of malignant tumors in the world every year, which is equivalent to one death every 5-6 seconds. The methods for treating tumors include...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10A61M36/00A61F7/03G21G4/08A61K51/10
Inventor 黄文旵王德平周萘姚爱华赵荻
Owner TONGJI UNIV
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