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Method for preparing medicament containing gambogic acid compounds and clathrate of gambogic acid compounds

A technology of gambogic acid and compounds, which is applied in the field of clathrate preparation, can solve problems such as unstable chemical properties, no clathrate patents and literatures, and restrictions on the application of gambogic acid compounds, achieving shortened time, The effect of high practical value

Inactive Publication Date: 2008-10-08
王效山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods solve the problem of water solubility, they cannot overcome their weaknesses such as large irritation, unstable chemical properties, and hemolysis, which limit the application of gambogic acid compounds.
[0004] By searching other domestic and foreign documents and patents, no patents and documents related to the inclusion of gambogic acid compounds using cyclodextrin derivatives have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Mix 1 gram of total gambogic acid and several grams of hydroxypropyl-β-cyclodextrin (or several grams of sulfobutyl ether-β-cyclodextrin) with 1000ml of absolute ethanol, heat and reflux at 60°C for 3 hours until the drug is completely dissolved , and concentrated under reduced pressure to constant weight to obtain clathrate.

Embodiment 2

[0023] Mix 1 gram of gambogic acid and several grams of hydroxypropyl-β-cyclodextrin (or several grams of sulfobutyl ether-β-cyclodextrin) with 1000ml of absolute ethanol, heat and reflux at 60°C for 3 hours until the drug is completely dissolved, Concentrate under reduced pressure to constant weight to obtain clathrate.

Embodiment 3

[0025] Mix 1 gram of begambogic acid and several grams of hydroxypropyl-β-cyclodextrin (or several grams of sulfobutyl ether-β-cyclodextrin) with 1000ml of absolute ethanol, heat and reflux at 60°C for 3 hours until the drug is completely dissolved , and concentrated under reduced pressure to constant weight to obtain clathrate.

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PUM

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Abstract

The invention discloses a drug containing gambogic acid compound and a preparation method of inclusion compound containing the gambogic acid compound. Cyclodextrin and derivative inclusion compound of the gambogic acid compound of the invention is the cyclodextrin and derivative inclusion compound of various effective components with biological activity in traditional Chinese medicine-gamboge. The preparation mainly contains powder and injection preparation, freeze-dry powder and injection preparation, troche (plain tablet, coating tablet, delayed release tablet and controlled release tablet), capsule, microcapsule, emulsion, micro emulsion and lipid body, etc. The inclusion compound containing the gambogic acid compound is added into the drug by the invention, thereby reducing toxicity and irritation of the drug, strengthening water-solubility, stability, security, etc. and having important theoretical and utility value for the gambogic acid compound in clinical application.

Description

technical field [0001] The invention belongs to a pharmaceutical preparation, and particularly relates to a preparation method of a drug containing gambogic acid compounds and an inclusion compound of the gambogic acid compounds. Background technique [0002] Garcinia hanbaryi Hook.f. is a dry resin secreted by Garcinia hanbaryi Hook.f., which is recorded in the United States Pharmacopoeia. acid (arroic acid). Most of them have anti-tumor effects, and are effective for lung cancer, liver cancer, colon cancer, ovarian cancer, and leukemia. For example, Qu Baoxi found that new gambogic acid has the effect on S 180 , ARS ascites cancer, Lewis lung cancer, leukemia and other solid cancers have a good inhibitory effect. Gambogic acid shows strong anti-tumor activity on various tumors, and its toxic and side effects are relatively small within the effective dose range. It has very high selectivity for the inhibition of tumor cells and can selectively kill cancer cells. Animal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/185A61K9/02A61K9/06A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K47/40A61P35/00A61K35/00
Inventor 王效山黄鹏董辉见玉娟
Owner 王效山
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