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Degradable polymer blood vessel stent drug-eluting containing anticoagulant choline phosphate composition

A technology for degrading polymers and drug coatings, applied in the field of medical devices, can solve the problems of carrier shedding, rough surface, strong hydrophobicity, etc.

Inactive Publication Date: 2008-09-17
天津百畅医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (3) More importantly, the surface of PLA material is highly hydrophobic, which affects its affinity with cells and drugs when it is used as a drug delivery material for tissue engineering scaffold materials
[0009] (4) The degradation method of this kind of degradable polymer, the bulk erosion spreads all over the carrier, the overall structure of the carrier will become loose, the water content will increase, the carrier will soon begin to disintegrate, the bonding force between the carrier and the bracket itself will decrease, and the carrier will be easily Shedding occurs, shortening the effective life of the drug film
[0010] (5) The surface of the material is rough before disintegration, which is easy to form thrombus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment one: after 0.3g polylactic acid (PDLLA), polyethylene glycol and phosphorylcholine copolymer are dissolved in 10ml acetone, add 0.2g superoxide dismutase ( SOD) stirred, dissolved evenly and filtered, sprayed on the bottom layer of the parylene (Parylene) polymer film and covered with 0.1g cyclosporin A and 0.3g polylactic acid (PDLLA) and polyethylene glycol copolymer intermediate drug-coated 316L stainless steel stent surface, volatilize the solvent in nitrogen, and rotate the angle of the stent to repeat spraying several times to make it evenly coated on the surface of the stent, volatilize the solvent in nitrogen and then vacuum Dry at room temperature for 12 hours under conditions. Sterilized by ethylene oxide.

Embodiment 2

[0034] Example 2: After 0.2g of polylactic acid (PDLLA) and phosphorylcholine blend was dissolved in 10ml of acetonitrile, 0.5g of lycopene, 0.01g of coenzyme Q10 and 0.01g of vitamin E were added After stirring, dissolving evenly and filtering, spraying on the bottom layer of the polyparaxylylene (Parylene) polymer film is covered with 0.1g dactinomycin and 0.3g polylactic acid (PDLLA) and polyethylene glycol copolymer intermediate drug-coated 316L stainless steel stent surface, volatilize the solvent in nitrogen, and repeat the spraying several times by rotating the angle of the stent to make it evenly coated on the surface of the stent, volatilize the solvent in nitrogen, and then spray it under vacuum conditions. Dry at room temperature for 12 hours. Sterilized by ethylene oxide.

Embodiment 3

[0035] Example 3: After 0.3g of polylactic acid (PDLLA), polyethylene glycol and phosphorylcholine copolymer was dissolved in 10ml of ethanol, 0.3g of coenzyme Q10 and 0.01g of thunderbolt were added Pamycin was stirred, dissolved evenly and filtered, sprayed onto the surface of a 316L stainless steel stent covered with a bottom layer of a parylene (Parylene) polymer film, and rotated the angle of the stent to repeat spraying several times to make it evenly coated on the surface of the stent. The solvent was evaporated in nitrogen and then dried at room temperature under vacuum for 12 hours. Sterilized by ethylene oxide.

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Abstract

The invention relates to a medical instrument field, in particular to a medicine coating layer of blood vessel support of degradation polymer with anti-coagulant phosphoric acid choline ingredient. The medicine coating layer is formed by 1 percent to 50 percent medicine and medicine carrier of 50 percent to 99 percent degradation polymer with anti-coagulant phosphoric acid choline ingredient. The medicine can choose individual oxidation resisting medicine, mixture of diverse oxidation resisting medicines, mixture of single or diverse blood vessel restenosis medicines, mixture of single or diverse oxidation resisting medicine and blood vessel restenosis medicine composition. The medicine carrier is a copolymer of three macromolecules of polylactic acid (PDLLA), polyethylene glyco and phosphoric acid choline. And the medicine and medical biological degradation polymer are coated uniformly on the surface of the blood vessel support by the mixing or stratification coating method. According to local medication, the thrombus incidence rate can be effectively eased and reduced, so that the restenosis of coronary artery can be finally cured.

Description

Technical field: [0001] The invention relates to the field of medical devices, in particular to a degradable polymer blood vessel stent drug coating containing anticoagulant phosphorylcholine components. Background technique: [0002] Atherosclerosis is an important disease that affects human health, and the disease that affects the coronary arteries of the heart is called coronary heart disease. Coronary heart disease often causes myocardial insufficiency, ranging from angina pectoris to myocardial infarction and even death. In 2000, ischemic heart disease accounted for 21.4% of all deaths in the United States, among which acute myocardial infarction accounted for 8%. Transcatheter interventional therapy is one of the most commonly used treatments for vascular obstructive diseases, especially percutaneous coronary angioplasty (PTCA) is a very effective treatment for coronary obstructive diseases. The polymer coating of the non-degradable stent currently used clinically is...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L33/00
Inventor 刘泊志张志刚王闻宇
Owner 天津百畅医疗器械有限公司
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