Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament

A technology for Grifola frondosa polysaccharide and viral diseases, which is applied in directions such as drug combinations, pharmaceutical formulations, organic active ingredients, etc., to achieve the effects of low treatment cost, good treatment effect, and no toxic and side effects

Active Publication Date: 2008-08-27
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on the clinical research and product development of Grifola frondosa polysaccharides for the prevention and treatment of porcine viral diseases

Method used

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  • Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament
  • Applications of ash tree flowers polysaccharide for preparing preventing and controlling pig virosis medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Study on Porcine Rotavirus Enteritis Treated by Grifola frondosa Polysaccharide

[0014] Materials and methods

[0015] Test animals, groups and test methods

[0016] According to clinical observation and laboratory diagnosis, the following 40 piglets diagnosed with rotavirus enteritis were selected and divided into treatment group and control group.

[0017] The treatment group had 20 cases in the control group, and the treatment group received intramuscular injection of Grifola frondosa polysaccharide at 5.0mg / Kg, 0.5ml / kg each time, twice a day. The control group was given Smecta orally, 0.01-0.15g / kg each time, twice a day. After the administration, the mental state, body temperature, shape and color of the feces and the suckling or feeding situation of the piglets were observed every day.

[0018] Judgment of curative effect

[0019] After 3 to 4 days of medication, the clinical symptoms disappeared, the feces formed, and the body temperature, appetite, and men...

Embodiment 2

[0026] Experimental Study on Prevention and Treatment of Porcine Epidemic Diarrhea with Grifola frondosa Polysaccharide

[0027] 1 Test animals, groups and test methods

[0028] 1.1 Feeding and management of test pigs All test piglets were reared with their sows in the farrowing house under the same conditions or raised on the concrete floor, and were routinely disinfected once a week.

[0029] 1.2 Treatment test According to clinical observations and laboratory tests, select 45 pigs aged 1 to 25 days who have been diagnosed with porcine epidemic diarrhea as follows. They were randomly divided into three groups A, B and C according to the same principle. The piglets in group A were intramuscularly injected with 8.0 mg / Kg of grifola frondosa polysaccharide; the piglets in group B and C were given intramuscular injection with normal saline and astragalus polysaccharide according to the recommended dosage of the drug. The three groups were treated once a day for 5 consecutive d...

Embodiment 3

[0037] An Example of Treating Porcine Transmissible Gastroenteritis with Grifola frondosa Polysaccharide

[0038] On March 5, 2008, the piglets in a certain farm in Tianjin had the same symptoms one after another: diarrhea, fever, lack of energy, and anorexia. After March 8, it was found that the mortality rate of pigs increased, and the feed intake decreased rapidly. Every 100 pigs per day 1 to 2 heads died, and the most serious death was about 6 heads per day.

[0039] In response to the above phenomenon, it is recommended to use Grifola frondosa polysaccharide intramuscular injection, 100mg / pig, for 3 to 5 days in a row. In addition, multidimensional electrolytes can quickly control death, restore the mental state of pigs, and significantly reduce the invention rate and mortality.

[0040] Analysis: Necropsy diagnosis and pathological diagnosis: porcine transmissible gastroenteritis.

[0041] Summary: Similar symptoms, early detection and early treatment, intramuscular inj...

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Abstract

The invention relates to the use of polysaccharides of Grifola frondosa in preparing drugs for controlling viral diseases in pigs, particularly to the use for controlling porcine rotavirus enteritis, porcine epidemic diarrhea and porcine transmissible gastroenteritis. For use, polysaccharides of Grifola frondosa are injected intramuscularly at a dose of 1.0-50 mg / kg, twice daily or mixed uniformly with a premix feed at a weight percentage of 0.1-10%. The premix feed is commercially available and pigs are fed ad libitum. The invention has the advantages that: the invention provide a new natural medicine for controlling viral diseases in pigs and improving porcine immunity in clinic; the natural medicine has high safety, definite effectiveness and controllable quality; and the natural medicine has easily-accessible raw materials, no toxicity and side effect and no risk of inducing drug resistance.

Description

technical field [0001] The invention relates to the application of the frondosa frondosa polysaccharide, in particular to the application of the frondosa frondosa polysaccharide in the preparation of medicines for preventing and treating viral diseases of pigs. Background technique [0002] Among pig diseases, virus infection is the most costly to the pig farming industry. In large-scale pig production, due to the influence of many factors, the incidence of viral diseases such as porcine parvovirus, swine fever virus, and porcine blue ear virus is as high as 5-50%, and the fatality rate is as high as 1%-10%. Pig production causes great economic losses. For example, among the various causes of porcine diarrhea, the harm of viral diarrhea is the most serious, which can cause the death of piglets, fat loss of adult pigs, reduction of feed remuneration, increase of labor costs and medical expenses. Porcine transmissible gastroenteritis, porcine epidemic diarrhea, and porcine r...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/04A61P1/12
Inventor 古长庆
Owner TIANJIN SHENGJI GRP CO LTD
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