Denaturated starch absorbable hemostatic material and preparation method thereof

Abstract

An absorbable modified starch hemostatic material and preparation thereof, wherein the hemostatic material is etherified starch, or a mixture of one or more etherified starches, crosslinked starches. The modified starch has a molecular weight of 15,000 - 10,000,000, a particle size of 10 - 1000µm, and a water absorption rate of 1 - 100. The biocompatible hemostatic material can directly effect on the wound with blood, concentrate the blood quickly to congulate blood; moreover, the gelatiniform mixture formed with blood has high viscosity, which can plug damaged tissue and blood vessel. The biocompatible hemostatic material is easy to swell in the water and easy to be washed so that the residue can be reduced; it is stable, not easy to decompose, and has long shelf life and storage advantage. The biocompatible hemostatic material can also be used as absorbable surgical antisticking material, promoting tissue healing material, surgical sealant and wound no-joint tissue adhesive.

Description

technical field [0001] The invention relates to a modified starch absorbable hemostatic material and a preparation method thereof, in particular to a modified starch hemostatic material which is directly sprayed on bloody wounds of humans and mammals for hemostasis and can be absorbed by the human body. Background technique [0002] Surgical operations and trauma usually cause bloody wounds, resulting in a large amount of blood loss, which requires timely use of hemostatic means. Here are some commonly used surgical absorbable hemostatic materials. [0003] 1. Absorbable gelatin sponge and collagen sponge [0004] Gelatin sponge is derived from the extract of animal tissue, and its main component is animal collagen. Its hydrophilic and porous structure can quickly absorb the water in the blood and concentrate the blood, so as to achieve the purpose of hemostasis. However, gelatin is a collagen extract derived from animals and contains foreign proteins, which can easily cau...

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) still lack effective means; The 2nd, from preparation method, epichlorohydrin is colorless oily liquid, has irritating smell like ether and chloroform, has toxicity and anesthesia, therefore unfavorable to environmental protection, production cost Thirdly, in terms of hemostatic effect, its water absorption is not strong enough, the water absorption multiple is low, and the speed of water absorption is slow, especially for active bleeding.

Fourth, its viscosity is low, and the gel formed after absorbing water has poor viscosity. Therefore, the clot formed after interacting with blood has poor adhesion to tissues, and cannot effectively block damaged tissues and blood vessels, thus affecting hemostasis. Effect

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