Dispersible tablet with gastrodia tuber for treating headache, and its testing method

A detection method and technology for dispersible tablets, which are applied in pharmaceutical formulations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problem of high local drug concentration, achieve rapid drug dissolution, convenient transportation, High bioavailability effect

Inactive Publication Date: 2009-07-29
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Tianshu capsules are widely used in the market, but the capsules have the disadvantages of high local drug concentration after patients take the medicine, while dispersible tablets are a kind of quick-acting preparation developed in recent years, and have the reputation of "solid oral liquid". , which combines the advantages of tablets and oral liquid preparations, overcomes the shortcomings of both, and can solve the problems existing in capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dispersible tablet with gastrodia tuber for treating headache, and its testing method
  • Dispersible tablet with gastrodia tuber for treating headache, and its testing method
  • Dispersible tablet with gastrodia tuber for treating headache, and its testing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0196] Embodiment 2 of the present invention: described quality control method comprises the following contents:

[0197] Properties: The drug is brown to brown tablets; it has a special aroma and a slightly bitter taste;

[0198] Identification: (1) Take 3 tablets of this preparation, grind them finely, add 15ml of water to dissolve, filter, shake the filtrate with 25ml of diethyl ether, discard the diethyl ether solution, shake the water layer with 20ml of n-butanol, separate and take n-butanol Alcoholic liquid, evaporated to dryness, add methanol 1ml to the residue to dissolve, as the test solution; take another gastrodin reference substance, add methanol to make a solution containing 0.5mg per 1ml, as the reference substance solution; according to the Chinese Pharmacopoeia 2005 edition one Appendix VIB Thin-layer chromatography test, draw 5 μl of each of the above two solutions, and place them on the same silica gel G thin-layer plate with sodium carboxymethylcellulose as ...

Embodiment 3

[0209] Embodiment 3 of the present invention: quality control method may comprise the following content:

[0210] Properties: The drug is brown to brown tablets; it has a special aroma and a slightly bitter taste;

[0211]Identification: Take 3 tablets of this preparation, grind them finely, add 15ml of water to dissolve, filter, shake the filtrate with 25ml of ether, discard the ether solution, shake the water layer with 20ml of n-butanol, separate the n-butanol solution, Evaporate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test solution; take another gastrodin reference substance, add methanol to make a solution containing 0.5mg per 1ml, and use it as the reference substance solution; according to the Chinese Pharmacopoeia 2005 edition one appendix VIB thin For layer chromatography test, draw 5 μl of each of the above two solutions, and spot them on the same silica gel G thin-layer plate with sodium carboxymethylcellulose as the binder, and...

Embodiment 4

[0218] Embodiment 4 of the present invention: quality control method may comprise the following content:

[0219] Properties: The drug is brown to brown tablets; it has a special aroma and a slightly bitter taste;

[0220] Identification: Take 2 tablets of this preparation, grind finely, add 20ml of ether, heat and reflux for 1 hour, filter, evaporate the filtrate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the test solution; Prepare the reference medicinal material solution according to the method; according to the Chinese Pharmacopoeia 2005 edition one appendix VIB thin-layer chromatography test, draw each 2 μ l of the above two solutions, respectively spot on the same silica gel G thin-layer plate, with n-hexane:ethyl acetate=9 : 1 is a developing agent, unfolded, taken out, dried, and inspected under an ultraviolet lamp, in the chromatogram of the test product, on the position corresponding to the chromatogram of the contrast medicinal ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a Tianshu dispersible tablet for treating headaches, a preparation method and a quality control method. Magnesium stearate and aspartame are prepared; compared with the prior art, the dispersible tablet of the present invention has the following advantages: the disintegration time is short, and the dispersion state is good; the medicine dissolves rapidly, absorbs quickly, and has high bioavailability; The production equipment is the same as that of ordinary tablets, which is suitable for large-scale industrial production; it is convenient to take and has various methods, especially suitable for the elderly, young and patients with difficulty swallowing; it is convenient to produce, carry, and transport, and the quality is stable. In addition, the quality control method of the present invention has high precision, good reproducibility and accurate measurement results, which can effectively guarantee the clinical curative effect of the preparation.

Description

Technical field: [0001] The invention relates to a Tianshu dispersible tablet for treating headaches and a detection method, belonging to the technical field of traditional Chinese medicine. Background technique: [0002] The effective medicines for treating migraine in traditional Chinese medicine are mainly Chuanxiong and Gastrodia elata preparations. Among them, Tianshu preparation is composed of Gastrodia elata and Chuanxiong. It has the effect of promoting blood circulation and calming the liver. For various types of headaches, studies have shown that the use of Tianshu preparations can relieve pain, shorten the time of headache attacks, especially control the number of attacks more ideally, greatly relieve the pain of patients who have been plagued by headaches all year round, and have no obvious adverse reactions. At present, Tianshu capsules are widely used in the market, but the capsules have the disadvantages of high local drug concentration after patients take the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61K9/20A61P25/04
Inventor 陈法贵王天兴徐丽君
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap