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Nerve growth factor external application medicine and its preparing method

A nerve growth factor, external use technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as limited applicable diseases, achieve long-lasting efficacy, prevent exposure to infection, and strong adhesion.

Active Publication Date: 2009-03-11
辽宁盛源文化发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are NGF injections in clinical use at present, the applicable diseases are limited. NGF should be used to replace antibiotics with a variety of dosage forms that are more applicable and more convenient and effective.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0012] Example 1: The mixed base component ratio of cream (A1): g / ml%

[0013] Azone 0.1-0.6, stearic acid 11-24, liquid paraffin 12-22.5, mixed castor oil, sesame oil, corn oil and sunflower oil 17-23, triethanolamine 0.4-1.25, glycerol 4-7, white petrolatum 0.5-2, benzoic acid 0.01-0.4, borneol 0.1-0.25, and the balance is water for injection.

example 2

[0014] Example 2: The ratio of the mixed base components of the cream (A2):

[0015] Azone 0.1-0.6, stearic acid 10-15, glyceryl monostearate 2.5-6 liquid paraffin 5-10, triethanolamine 0.3-1.25, white petrolatum 0.25-2, lanolin 2-7, paraben B Ester 0.05-0.2, borneol 0.1-0.25, and the balance is water for injection.

example 3

[0016] Example 3: The mixed base component ratio of cream (A3):

[0017] Ledum oil 0.1-0.6, stearyl alcohol 21-25, sodium lauryl alcoholate 0.5-2.5, triethanolamine 0.4-1.25, glycerol 10-15, white petrolatum 18-26, methylparaben 0.01-0.03 , ethylparaben 0.01-0.02, borneol 0.1-0.25, and the balance is water for injection.

[0018] Stearyl alcohol can also be replaced by cetyl alcohol, and glycerol can also be replaced by propylene glycol.

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PUM

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Abstract

The externally applied nerve growth factor (NGF) medicine preparation includes NGF emulsified paste and NGF emulsion. The NGF emulsified paste has the components including NGF, borneol and mixed matrix, and the mixed matrix comprises azone, stearic acid, liquid paraffin, castor oil, triethanolamine, glycerin, white vaseline, benzoic acid and water for injection. The preparation process of the NGF emulsified paste heating the mixed matrix in water bath to 70-85 deg.c through stirring for full emulsification, cooling to room temperature, adding borneol and NGF to obtain the NGF emulsified paste.

Description

technical field [0001] The invention relates to a nerve growth factor external-use medicine for treating dermatology, gynecology, surgery and other diseases and a preparation method thereof. Background technique [0002] With the development of modern medicine, various new drugs are constantly released, especially the wide application of antibiotics, which has played a certain role in various skin diseases. Although antibiotics are used for some chronic diseases and receive certain curative effect, due to long-term use, the drug resistance of bacteria has affected the curative effect of antibiotics. Bacterial drug resistance has attracted the attention of the whole society. It is the common goal of colleagues at home and abroad to find effective treatment methods and provide new drugs with high curative effect, convenient use, short course of treatment and less side effects to replace antibiotics. In the past, antihistamine drugs and steroid ointments were mainly used in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K9/06A61K9/00A61P17/02A61P15/00
Inventor 孙晋民郝文学刘海军詹丽芬那秀莲李艳超郑华川王英珏刘冲迟晓明
Owner 辽宁盛源文化发展有限公司
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