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Anti-allergic traditional Chinese medicine composition and preparing method thereof

An allergy and composition technology, applied in the direction of drug combination, test drug preparations, anti-inflammatory agents, etc., can solve the problems of patient death, toxic side effects, double infection, etc., and achieve good application prospects and no toxic and side effects

Inactive Publication Date: 2007-09-05
霍玉书
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after long-term use of adrenal corticosteroids, many toxic and side effects are found, especially in the absence of effective control of pathogens, due to immunosuppression, antibody production is affected (so some patients may detect antibody titers decreased), leading to the spread of pathogens and superinfection , hemorrhage of vital organs, glucose metabolism and electrolyte disturbance, etc., and even lead to rescue failure and death of some patients

Method used

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  • Anti-allergic traditional Chinese medicine composition and preparing method thereof
  • Anti-allergic traditional Chinese medicine composition and preparing method thereof
  • Anti-allergic traditional Chinese medicine composition and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] Experimental Example 1: Inhibition of COX2 and anti-free radical effect of Leuteng anti-inflammatory agent (in vitro experiment)

[0020] Materials and Methods:

[0021] Add 2mM glutamine, 25mM, Hepes, penicillin (100u / ml), streptomycin (100μg / ml), 10% foetal bovine serum to the murine macrophage / monocyte (The murine monocyte / macrophage) J774 cell line (FBS) and 1.2% Na pyruvate (Bio Whittaker, Europe). Cells were added to 24-well plate for culture. The number of cells is 2.5×10 5 Cells / ml. Incubate at 5% CO2 / 95% O2 at 37°C for 2 hours. Immediately wash the cells with fresh medium containing FBS. Add Arachidonic acid (AA) 15×10 -6M (Zingarelli et al., 1997) were cultured for another 30 minutes. The supernatant was collected by centrifugation to measure PGE2 in the culture medium by radioimmunoassay and then used to calculate COX-1 activity. (Sautebin et al., 1999). After the cells were washed, the culture medium was added, and E.Coli lipopolysaccharide (LPS, 10 μg / m...

experiment example 2

[0023] Experimental Example 2: Anti-radiation-induced free radical effect of Liangteng anti-inflammatory agent

[0024] 1. Principle: Lipid peroxide (LPO) is a lipid peroxide formed by unsaturated fatty acids attacked by free radicals. Unsaturated fatty acids mainly exist in cell membranes, subcellular structures and platelets. It is a component of phospholipids, lipoproteins and cholesterol. If a large amount of LPO is formed, it will inevitably cause cell damage and affect cell function. Therefore, according to the free radical theory of aging, LPO can increase with the increase. Therefore, the LPO content in the blood and major organs of aged animals can be higher than that of non-aged animals. If sub-dose 60 Free radicals induced by Co irradiation can also cause high LPO models. In order to prove the antioxidant effect of this product. For this test

[0025] 2. Materials and methods:

[0026] 20 six-month-old female Kunming mice weighing 34-38 g (provided by the Expe...

Embodiment 1

[0047] Example 1 tablet

[0048] Bright Leaf Poplar 100g Uncaria 50g

[0049] Cicada slough 50g Viola 50g

[0050] Ganoderma lucidum spore powder 50g

[0051] Pulverize poplar, uncaria, cicada slough and Viola chinensis separately, mix, soak in 95% ethanol for 24 hours, twice, combine the extracts, recover alcohol, dry at 80 degrees Celsius, the yield is 23-26%, and Ganoderma lucidum spore powder is mixed, 50 grams are weighed and 10% dextrin is added, conventionally granulated, 100 grams of granules are made, excipients are added, and tabletted (the granulation tablet machine completes once). Each piece weighs 0.5 grams.

[0052] Usage and dosage: 2-4 tablets each time, 3 times a day.

[0053] Indications: Symptomatic treatment of various acute febrile infectious diseases, rheumatoid arthritis, allergic diseases, insomnia, anxiety.

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Abstract

The present invention discloses a Chinese medicine composition having anti-allergic reaction and selective cyclooxygenase 2 inhibition functions and a preparing method and a quality control method thereof. The composition is mainly composed of bright leaf Tung, hooked uncaria, cicada slough, viola yedoensis, and glossy ganoderma spore powder. When preparing the Chinese medicine composition, the bright leaf Tung, the hooked uncaria, the cicada slough and the viola yedoensis are crushed and mixed, and then the mixture is dipped by 80-95% ethanol for 22-28 hours for one to three times, the extracted liquid is collected and the ethanol is reclaimed, the mixture is then dried under 70-85 DEG C, the reclaim rate is 20-28%, and the mixture is mixed with glossy ganoderma spore powder and is made to acceptable preparation in clinic directly by conventional procedure or by adding acceptable excipient in pharmacy. The invention also provides a quality control method for discriminating the components and measuring the content for the composition. The composition has excellent anti-allergic reaction and selective cyclooxygenase 2 inhibition functions.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for anti-inflammatory allergy and selective cyclooxygenase 2 inhibition, as well as a preparation method and a quality control method of the composition. Background technique [0002] In the pathophysiological process of various acute severe infectious diseases, the excessive acute inflammatory response severely damages the body and major target organs, leading to multiple organ failure, which is one of the main causes of death in most patients with acute infectious diseases. Excessive immune response is an important manifestation of immune response disorders, including different types of responses, collectively referred to as allergic reactions. Such as serum shock, Assas reaction, delayed allergic reaction, and antibody-dependent cell-mediated cytotoxicity (ADCC.antibody-dependent cell-mediated cytotoxicity). [0003] A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K36/82A61K36/074A61K35/64A61P29/00A61P37/08G01N30/90G01N33/15
Inventor 霍玉书霍虹
Owner 霍玉书
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