Tobacco and/or tobacco substitute composition for use as a snuff in the oral cavity
a technology of composition and tobacco, which is applied in the field of composition for the use of snuff in the oral cavity, can solve the problems of not being able to avoid or reduce the release of potentially harmful and unwanted substances, unable to meet the needs of patients,
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example 1
also shows that some hydrophobic membranes, e.g. vinyl and polyethylene membranes, have a slower nicotine release profile compared to the hydrophilic membranes.
All these observations make it possible to design membranes, which enable a specific release of nicotine, i.e. it is possible to design membranes having desired release characteristics e.g. a quick or a slow release of nicotine dependent on the purpose of the composition. In other words, the specific features of a membrane or a membrane material can be used to design a controlled and well-defined release profile for the release of nicotine from a composition according to the invention.
TABLE 2Release of nicotine from membranes of various kinds,thicknesses and pore sizesRelease of nicotine (%)Membrane0 min3 min30 min90 min120 min180 minReference filter4.718.746.580.888.8100(original)23 μm2.44.136.673.283.7100cellulose membrane13,000 MW cut-off46 μm cellulose1.62.433.369.179.2100membrane13,000 MW cut-off93 μm cellulose0017.24...
example 3
Optimization of Membrane Properties with Respect to Molecular Weight Cut-Off, Thickness and Low IPI Values
example 2
shows that no significant loss in membrane selectivity μs observed as the membrane thickness is being decreased. Therefore, further studies to investigate the relationship between membrane thickness, molecular weight cut-off of the membrane and amount of nicotine transferred over the membrane were performed by analyzing selected data from Example 1.
From FIG. 1, the maximum slope for each release profile has been deduced. The maximum slope, i.e. percentage nicotine release per time unit, dR / dt represents the maximum flux of nicotine through the membranes (see Table 4).
TABLE 4Values for the maximum flux (% nicotine released pertime unit, dR / dt) and lag time for different thicknesses ofmembranes with cut off 3500 Mw, 13000 Mw and reference filterMaximum fluxMolecular weightThicknessLag timeof nicotinecut-off(μm)(min)(dR / dt)∞01.250(reference pouch)13,000 MW CO23.201.205membrane46.401.14492.800.6373,500 MW CO25.2≈501.250membrane50.4≈501.204
FIG. 3 shows a plot of the maximum flux as a ...
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