The invention discloses a computer display screen packaging box. The computer display screen packaging box comprises a box body and a display screen body, wherein a box cover is hinged to the upper portion of the box body, a rubber pad is arranged on the inner bottom side of the box cover, springs are symmetrically mounted on the inner side wall of the box cover, above the rubber pad, through spring seats, the other ends of the springs are fixedly connected with the central positions of one sides of pressing blocks, the display screen body is arranged between the pressing blocks, two air bagsare arranged between the two sides of the display screen body and the inner side wall of the box body, a dustproof cover plate is arranged at the position, located in the box opening, of the interiorof the box body, buckling pieces are hinged to the outer side of the box cover, and inserting pieces are welded on the inner sides of the bottoms of the buckling pieces. According to the computer display screen packaging box, a good damping effect is achieved, and meanwhile, the fixing effect is good; the computer display screen can be effectively prevented from being damaged caused by toppling ortoo large vibration in the transportation process; and the computer display screen packaging box has a good dustproof effect and is worthy of popularization and popularization.