The invention relates to a locking-type multi-mode four-rod variable valve driving system, and belongs to the field of engine valve driving. The locking-type multi-mode four-rod variable valve driving system mainly comprises a camshaft, a mode input mechanism, a mode output mechanism, a mode switching mechanism, a valve adjusting mechanism, a valve control mechanism and the like. By the adoption of the mode switching mechanism, an engine can be switched between multiple modes including a two-stroke driving mode, a four-stroke driving mode, a two-stroke braking mode, a four-stroke braking mode and the like. Furthermore, due to the fact that the mode switching mechanism and the valve control mechanism are matched for use, optimal ventilation of the engine under different working conditions is realized ultimately, and the purpose of comprehensively improving the engine dynamic property, fuel economy, emission performance and braking safety is achieved. The locking-type multi-mode four-rod variable valve driving system is put forward oriented to practical applications, reliability is high, the structure is compact, the requirements for all the mechanisms by the system are lowered, mature technologies are adopted in all the mechanisms, the practical potential of the system in the short term is high, and the application prospects are good.