Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bioresorbable metal alloy and implants made of same

a bioresorbable metal alloy and metal alloy technology, applied in the field of bioresorbable metal alloy and implants made of same, can solve the problems of toxic alloying elements deformation in the human body, etc., and achieve the effects of excellent implant material, high corrosion rate, and optimal mechanical functionality

Inactive Publication Date: 2017-03-23
UNIV OF FLORIDA RES FOUNDATION INC
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes the researchers' development of a magnesium-based alloy that can be used as a biomedical implant material. The alloy is designed to have optimal mechanical functionality and maintain biocompatibility by selecting the alloying elements calcium and strontium, which are essential elements for the human body. The alloy can completely dissolve within the body and release dissolution products that are 100% biocompatible and enhance the biological processes in bone. The researchers have shown that the magnesium-based alloy system containing calcium and strontium will produce promising results, reducing the risk of potential toxicity by the degradation products being released from the medical device. Overall, this development provides an improvement over other magnesium alloy systems being investigated as both calcium and strontium are elements present in bones and are biocompatible whereas the alloying elements being used in other studies are toxic.

Problems solved by technology

It has a high corrosion rate, especially in chloride containing solutions, which means that it will degrade in the human body.
As a result, most of the alloys currently being investigated contain toxic alloying elements.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bioresorbable metal alloy and implants made of same
  • Bioresorbable metal alloy and implants made of same
  • Bioresorbable metal alloy and implants made of same

Examples

Experimental program
Comparison scheme
Effect test

example 1

Alloy Preparation

[0026]In this study, five different Mg—Ca—Sr alloys with targeted compositions of Mg-0.5Ca-0.5Sr,Mg-1.0Ca-0.5Sr, Mg-1.0Ca-1.0Sr, Mg-1.0Ca-2.0Sr and Mg-7.0Ca-3.5Sr were prepared using high purity Mg chips (99.98%, Sigma-Aldrich, St. Louis, Mo.), Ca granules (99.5%, Alfa- Aesar, Ward Hill, Mass.) and Sr granules (99%, Sigma-Aldrich, St. Louis, Mo.). Melting of the alloys was carried out between 725-825° C. in high purity graphite crucibles. Each melt was held for approximately 40 min and stirred prior to pouring. The melt was then poured into high purity graphite moulds that were allowed to air-cool to room temperature. A protective argon atmosphere was maintained throughout the melting and casting process. The compositions of the as cast alloys were determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). The nominal and actual compositions of the investigated Mg alloys are listed in Table 2

example 2

Microstructural Characterization

[0027]For microscopic evaluation, the samples were ground with silicon carbide (SiC) emery papers to 4000 grit, and polished to 0.3 micron using a colloidal silica suspension. The polished samples were etched using acetic picral as an etchant. The microstructural analysis was performed using light optic microscopy (LOM, Olympus PME3) and scanning electron microscopy (SEM, JEOL JSM 6400). Energy-dispersive X-ray spectroscopy (EDS, JEOL JSM 6400) and XRD (Phillips APD 3720) was employed to identify the different phases present in the alloys and the corroded surfaces.

example 3

Immersion Tests

[0028]The samples were ground to 320 grit using SiC emery paper and then cleaned with ethanol. The immersion test was carried out at 37° C. in Hanks balanced salt solution containing 0.185 g / l CaCl2.2H2O, 0.40 g / l KCl,0.06 g / l KH2PO4, 0.10 g / l MgCl2.6H2O, 0.10 g / l MgSO4.7H2O, 8.00 g / l NaCl,1, 0.35 gl NaHCO3, 0.48 g / l Na2HPO4, 1.0 g / l D-Glucose (Thermo Scientific Inc., Waltham, Mass.). The ratio of Hanks solution to the surface area of the samples was kept approximately 150. The high value was chosen to minimize the change in pH value during the experiment. The hydrogen evolution was measured by placing the samples at the bottom of a beaker with a funnel and a measuring cylinder placed on top of the beaker to collect and measure the volume of hydrogen gas evolved.13 The gas volume was measured every 24 h up to 8 days. The tests were performed in triplicates and the average of the data is reported.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
diameteraaaaaaaaaa
pore sizeaaaaaaaaaa
Login to View More

Abstract

Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of 35 U.S.C. §371 national stage application Ser. No. 13 / 808,037, entitled “BIORESORBABLE METAL ALLOY AND IMPLANTS MADE OF SAME”, filed on Jun. 7, 2013, which claims priority to PCT Application No. PCT / US2011 / 042892, entitled “BIORESORBABLE METAL ALLOY AND IMPLANTS MADE OF SAME”, filed on Jul. 2, 2011, which claims priority to and the benefit of U.S. Provisional Application No. 61 / 361327, entitled “BIORESORBABLE METAL ALLOY AND IMPLANTS MADE OF SAME”, filed Jul. 2, 2010, the entire contents of which are incorporated herein in their entirety.BACKGROUND OF THE INVENTION[0002]Biomaterials are used in numerous medical applications today, such as fixation devices, replacements and surgical equipment. Implants are typical examples of a biomaterial application and there are several different implant materials used today. Many of these are however designed to stay in the body permanently even though ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61L27/04A61L31/02C22C23/00A61L27/54A61L31/16A61L27/58A61L31/14
CPCA61L27/047A61L27/58A61L31/022A61L31/148A61L2430/12A61L31/16C22C23/00A61L2430/02A61L2430/38A61L27/54A61K33/06
Inventor MANUEL, MICHELEBRAR, HARPREET SINGHSVENSSON BERGLUND, IDA E.SARNTINORANONT, MALISAKESELOWSKY, BENJAMIN G.
Owner UNIV OF FLORIDA RES FOUNDATION INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com