Compositions comprising alprazolam for treating primary insomnia and insomnia associate with anxiety states and process for preparing them
a technology of insomnia and compositions, applied in the field of compositions comprising alprazolam for treating primary insomnia and insomnia associate with anxiety states, can solve the problems of affecting the effect of the body, and affecting the recovery process, so as to achieve rapid disintegration and rapid start of therapeutic action.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
Problems solved by technology
Method used
Image
Examples
example 1
Formula for 10,000 Sublingual or Buccal Tablets of 0.5 mg Alprazolam
[0107]
Alprazolam5gCross-linked carboxymethylcellulose3.5gFlavoringq.s.Lactose82gPovidone3.5gSodium Stearyl Fumarate3.5gMicrocrystalline Cellulose q.s.350g
[0108]5 g alprazolam were dissolved in 130 g of ethanol to prepare 10,000 tablets. Then, 3.5 g povidone were dissolved in this solution.
[0109]0.875 g cross-linked carboxymethylcellulose (25% of the formula) and the indicated amounts of microcrystalline cellulose and lactose were placed in the container of a high speed mixer-granulator. This was stirred and then the binding liquid was added to the powder mixture until a consistent granule was formed. The granulate was dried in a fluid circulating bed drier until the solvent was removed.
[0110]The dried granulate was calibrated in a conical sieve mill until a uniform particle size was obtained. The granulate obtained was added to a container. The flavorings were added, as well as 75% of the amount calculated of cross-...
example 2
Formula for 10,000 Sublingual or Buccal Tablets of 1 mg Alprazolam
[0116]
Alprazolam10gCross-linked carboxymethylcellulose3.5gFlavoringsq.s.Lactose82gPovidone3.5gSodium stearyl fumarate3.5gMycrocrystalline cellulose q.s.350g
[0117]To prepare 10,000 tablets 10 g alprazolam were dissolved in 180 g ethanol. In this solution was dissolved 3.5 g of povidone.
[0118]0.875 g of cross-linked carboxymethylcellulose (25% of the formula) and the indicated amounts of microcrystalline cellulose and lactose were placed in the container of a high speed mixer-granulator. This was stirred and then the binding liquid was added to the powder mixture until a consistent granule was formed. The granulate was dried in a fluid circulating bed drier until the solvent was removed.
[0119]The dried granulate was calibrated in a conical sieve mill until a uniform size of particle was obtained. The obtained granulate was added to a container. The flavorings were added, as well as 75% of the amount calculated of cross-...
example 3
Formula for 10,000 Sublingual or Buccal Tablets of 0.25 mg Alprazolam
[0125]
Alprazolam2.5gCross-linked carboxymethylcellulose3.5gFlavoringsq.s.Lactose82gPovidone3.5gSodium stearyl fumarate3.5gMycrocrystalline cellulose q.s.350g
[0126]2.5 g alprazolam was dissolved en 130 g ethanol to prepare 10,000 tablets. In this solution, 3.5 g povidone was dissolved.
[0127]0.875 g cross-linked carboxymethylcellulose (25% of the formula) and the indicated amounts of microcrystalline cellulose and lactose were placed in the container of a high speed mixer-granulator. This was stirred and then the binding liquid was added to the powder mixture until a consistent granule was formed. The granulate was dried in a fluid circulating bed drier until the solvent was removed.
[0128]The dried granulate was calibrated in a conical sieve mill until a uniform size of particle was obtained. The obtained granulate was added to a container. The flavorings were added, as well as 75% of the amount calculated of cross-l...
PUM
Property | Measurement | Unit |
---|---|---|
Weight | aaaaa | aaaaa |
Weight | aaaaa | aaaaa |
Fraction | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com