Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Troxerutin and barren wort flavones are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating coronary disease, angina pectoris, arrhythmia, cerebral thrombus, cerebral ischemia, hypertension, thrombotic phlebitis, capillary vessel hemorrhage, and decreased immune function.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] At present, about 4 million people die from cardiovascular and cerebrovascular diseases in my country every year, accounting for more than 3 / 5 of the death toll, and it has become the primary factor threatening human health. Although there are a large number of Chinese and Western medicine interviews at present, with the continuous change of disease spectrum and the arrival of aging age, the current medicine continues to show its limitations. Therefore, research and development of medicines for the treatment of cardiovascular and cerebrovascular diseases are always Become the focus and hot spot of people's attention. [0003] A large number of literatures have reported that the total flavonoids of Epimediu...

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Problems solved by technology

[0003] A large number of literatures have reported that the total flavonoids of Epimedium can inhibit myocardial contractility, and can significantly reduce peripheral resistance, increase left ventricular output, reduce cardiac load, increase peripheral organ perfusion, dilate blood vessels, lower blood pressure, improve cerebral ischemia and Cerebral hypoxia, significantly reduce whole blood viscosity at medium and low shear rates, reduce adhesion angle and red blood cell aggregation, reduce blood lipids, blood sugar, promote bone growth, prevent calcium loss, prevent osteoporosis, and have sex hormones anti-aging, anti-inflammation, anti-virus, anti-tumor, etc.; but because most of the drugs on the market use medicinal materials as medicine, the quality is difficult to guarantee, the dosage is large, the hygienic indicators are not easy to control, and the curative effect fluctuates greatly; Ding can inhibit platelet aggregation and prevent thrombus formation. At the same time, it can resist blood vessel damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent blood vessel permeability caused by increased blood vessel permeability. It is mainly used for diseases such as ischemic cerebrovascular disease (such as cerebral thrombosis, cerebral embolism), thrombophlebitis, central retinitis, edema caused by increased vascular permeability; but because troxerutin has certain side effects, so it is limited in clinical use; for this reason, the inventor adopts the effective parts of the total flavonoids of Epimedium to be directly used as medicine, and the compatibility of troxerutin examines its molding process and drug effect, and simultaneously studies the total flavonoids of Epimedium. The optimal ratio range of flavonoids and troxerutin compatibility provides the possibility for wider application of epimedium and troxerutin preparations, and at the same time provides patients with a more safe and effective medicine with a small range of curative effect fluctuations and less toxic and side effects. pharmaceutical preparations