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Oral disintegration tablet of Loratadine ambroxol, and prepartion method

A technology for oral disintegrating tablets and loratadine, which is applied in directions such as pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problem that no related literature about compound loratadine ambroxol oral disintegrating tablets has been found. and patent reporting

Inactive Publication Date: 2007-02-21
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the search, there are no relevant literature and patent reports about compound loratadine ambroxol orally disintegrating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation:

[0025] Add loratadine and ambroxol hydrochloride to Eudragit L30D suspension, add appropriate amount of water, stir well, then add crospovidone, mannitol, aspartame, and stir while adding to form a suspension Finally, pour it into a suitable mold, freeze it quickly, dry it under reduced pressure, take the mold, press seal it, and pack it.

Embodiment 2

[0028] Preparation:

[0029] Add loratadine and ambroxol hydrochloride to the mixture of guar gum and xanthan gum, stir evenly, add sucrose, xylitol, stevioside, stir while adding to form a uniform suspension, and pour Quickly freeze in a suitable mold, dry under reduced pressure, take the mold, press seal, and pack.

Embodiment 3

[0032] Preparation:

[0033] Mix the loratadine, ambroxol hydrochloride, L-HPC, PPVP, and sorbitol all passed through the 80-mesh sieve evenly according to the equal volume addition method, and mix the peach flavor with the above mixture, add magnesium stearate and mix Uniform, the powder can be directly compressed into tablets.

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PUM

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Abstract

An oral disintegrating tablet of compound clarityne-ambroxol for treating cough and allergic rhinitis is prepared from clarityne and ambroxol hydrochloride. Its preparing is also disclosed.

Description

technical field [0001] The invention relates to a compound loratadine ambroxol orally disintegrating tablet for relieving cough accompanied by abnormal secretion and related symptoms of allergic rhinitis, such as sneezing, runny nose, nasal itching, tearing, etc. and its preparation method. Background technique [0002] Ambroxol hydrochloride is a new generation of respiratory mucus regulator, and it is also the most effective expectorant in clinical practice. It has excellent expectorant effect and can significantly promote the synthesis and secretion of alveolar surfactant. Ambroxol hydrochloride can stimulate bronchial mucus glands to secrete more flowable mucus, dilute sputum, reduce viscosity, and increase the production and secretion of pulmonary surfactant, thereby reducing airway resistance, reducing mucus adhesion, and activating Mucociliary blanket functions to facilitate mucociliary transport. Compared with the first-generation and second-generation expectorant...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7048A61K31/4545A61P11/14A61P37/08
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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