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Piduomode soft capsule and its prepn. method

A technology of soft capsules and capsules, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc., can solve problems such as affecting the stability of preparations, unstable blood drug concentration, and poor environmental protection.

Inactive Publication Date: 2006-11-29
宛六一 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings of the existing oral preparation tablets of pidotimod, such as unstable blood drug concentration in the body, pidotimod tablets are easy to absorb moisture and affect the stability of the preparation, and poor environmental protection during production, we have undergone a lot of experiments Research, invented pidotimod soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] Preparation of contents: take pidotimod, diluent (polyethylene glycol 400-600 liquid polyethylene glycol series, fish oil, soybean oil, refined peanut oil, evening primrose oil, milk thistle oil, grape seed oil , sunflower oil, safflower oil, seabuckthorn oil, olive oil and other animal and vegetable oils suitable for the preparation of soft capsule contents), solubilizers (C3-C8 lower alcohols or their mixtures, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor Sesame oil, corn gluten, hydrogenated palm oil, triglycerides, diglycerides, monoglycerides, soybean lecithin, lecithin, polyglycerol lipids, sucrose lipids), solubilizers (ethanol, hydroxypropyl β-ring Dextrin, meglumine, triethanolamine, monoethanolamine, diethanolamine, dimethylformamide, diethylformamide, N,N-dimethylacetamide), suspending agent (PEG4000 or PEG6000 solid polyethylene Glycols, fumed silica, liquid paraffin, lanolin, beeswax, glyceryl monostearate, higher fatty alcohols), surfact...

Embodiment 1

[0023] Pidotimod 200g

[0024] PEG400 250g

[0025] Make 1000 capsules

[0026] Glue formula: gelatin (dry weight): purified water: glycerin = 1: 0.9: 0.4

Embodiment 2

[0028] Pidotimod 400g

[0029] PEG400 300g

[0030] PEG4000 6g

[0031] Make 1000 capsules

[0032] Glue formula: gelatin (dry weight): purified water: glycerin = 1: 0.8: 0.5

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PUM

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Abstract

A pidotimod soft capsule is prepared from pidotimod and assistant chosen from diluent, cosolvent, solubilizer, suspending aid, and surfactant through proportional mixing, preparing soft capsule, solidifying by cooling in wind, drying, washing with proper solvent and drying.

Description

field of invention [0001] The invention relates to a pidotimod soft capsule preparation as an active ingredient and a preparation method thereof. Background technique [0002] Pidotimod is a new immune enhancer, its structure is similar to thymosin. Studies have shown that pidotimod can promote both specific immunity and non-specific immunity, and exert anti-bacterial, anti-viral and anti-fungal effects by enhancing the body's cellular immunity and humoral immunity. [0003] Clinical application shows that pidotimod preparations are used to prevent and treat recurrent respiratory infections in children, chronic bronchitis in the elderly, recurrent urinary tract infections, malignant tumors and adjuvant therapy after chemotherapy and radiotherapy, with reliable curative effect and good human tolerance , less toxic and side effects. [0004] At present, the main oral dosage forms in China are tablets. The blood concentration of ordinary tablets in the body cannot show a stab...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/427A61K47/14A61K47/18A61K47/30A61P37/04
Inventor 宛六一
Owner 宛六一
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