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Flunarizine hydro-chloride capsule pill

A technology of flunarizine hydrochloride capsules and flunarizine hydrochloride, which can be applied in the directions of cardiovascular system diseases, drug combinations, etc., can solve problems such as differences in bioavailability, affect curative effect, affect drug dissolution rate, etc., and achieve bioavailability. The effect of high degree and stable dissolution rate

Inactive Publication Date: 2003-01-22
李大鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the drug is very slightly soluble in water, and the production process of each manufacturer is different, it directly affects the dissolution rate of the drug in the human body, thus easily causing differences in bioavailability, thereby affecting the curative effect

Method used

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Examples

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Effect test

Embodiment Construction

[0006] The flunarizine hydrochloride capsules of the present invention comprise flunarizine hydrochloride, and the flunarizine hydrochloride is sealed in the capsules in a liquid state.

[0007] During production, pulverize flunarizine hydrochloride and pass through a 100-mesh sieve; add a surfactant to polyethylene glycol-400, with Tween-80 as the first choice, and the addition is less than 1%, and stir well; at this time, the hydrochloric acid Flunarizine powder is added to the above liquid and stirred until dissolved, then compressed into capsules of 400-600 mg / capsule by conventional technology, each capsule contains 0.5 mg of flunarizine hydrochloride as flunarizine. The technical parts not described in detail in the present invention are all known technologies.

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Abstract

The flunarizine hydrochloride capsule has capsulized liquid flunarizine hydrochloride and has relatively stable digestion rate in human body and rather high biological utilization.

Description

technical field [0001] The invention relates to the technical field of flunarizine hydrochloride capsule preparations. Background technique [0002] Clinically, flunarizine hydrochloride is a drug for treating cerebrovascular diseases, such as treating cerebral insufficiency, vertebral artery ischemia, cerebral thrombosis and other cerebrovascular diseases. It has been clinically proven that flunarizine hydrochloride has a stronger expansion effect on cerebral blood vessels than on coronary arteries and mesenteric arteries. It can increase cerebral blood flow at a dose that does not cause a drop in systemic blood pressure, and it is currently the only calcium channel blocker. The only drug in the drug that can pass the blood-brain barrier. At present, the traditional preparations of this medicine are mostly capsules and tablets. Since the drug is very slightly soluble in water, and the production process of each manufacturer is different, it directly affects the dissolutio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61P9/10
Inventor 李大鹏梁泓李思
Owner 李大鹏
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