Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antipyetics hydrogen chloride tilidine compound formulation

A technology of compound preparation of tiridine hydrochloride, which is applied in the field of a compound preparation of the analgesic drug tiridine hydrochloride, can solve problems affecting curative effect and clinical use

Inactive Publication Date: 2005-12-21
岳振江
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Affect efficacy and clinical use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antipyetics hydrogen chloride tilidine compound formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take by weighing 40 grams of tiridine hydrochloride, 8 grams of nalotone hydrochloride, add 35 grams of pregelatinized starch, 15 grams of microcrystalline cellulose, take 20 grams of hypromellose, and mix evenly with 40 grams of polyethylene glycol 6000, Add 15% starch slurry to make a soft material, the soft material is granulated through a 14-mesh sieve and dried at 50°C, the dry granules are granulated through a 14-mesh sieve, and 5 grams of cross-linked carboxymethyl starch and 5 grams of magnesium stearate are added and mixed evenly. After passing the inspection, it is pressed into tablets or filled into hard capsules. After passing the inspection, use LE coating agent to coat with film, pack in aluminum-plastic (aluminum-inscribed) and outer pack to get ready.

Embodiment 2

[0025] Weigh 30 grams of tiridine hydrochloride, 5 grams of nalotone hydrochloride, add 30 grams of mannitol, and 35 grams of microcrystalline cellulose. 10 grams of cross-linked polyvinyl pyrrolidone and 15 grams of polyethylene glycol 4000 are mixed evenly, and 5 grams of 5% povidone absolute ethanol solution is added to make a suitable soft material. The soft material is granulated through a 14-mesh sieve, and 50 Dry at ℃, the dry granules are sized through a 14-mesh sieve, add 5 grams of croscarmellose starch sodium, 3 grams of talc powder, and 2 grams of magnesium stearate, mix well, press or fill the tablets after passing the inspection, and use LE after the tablet inspection is passed. The coating agent is coated with film, aluminum-plastic (aluminum-aluminum) packaging and outer packaging are ready.

Embodiment 3

[0027] Weigh 30 grams of tiridine hydrochloride, 4 grams of nalotone hydrochloride, add 20 grams of xylitol, and 20 grams of sodium starch glycolate. Cross-linked polyvinylpyrrolidone 40 grams. Mix 40 grams of polyethylene glycol 6000 evenly, add 30 grams of 3% polydimensional copper anhydrous ethanol solution to make a suitable soft material, the soft material is granulated through a 14-mesh sieve, dried at 50°C, and the dry granules are granulated through a 14-mesh sieve , add 5 grams of sodium carboxymethyl starch, 3 grams of talcum powder, mix evenly, press the tablet or fill if it passes the inspection, use LE coating film coating after the tablet inspection is passed, pack in aluminum-plastic (aluminum-aluminum), and outer packaging to get final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a new type analgesic compound preparation and its preparation method. Said invention uses tilidine hydrochloride as main raw material, and adds naloxone hydrochloride and optimizes filling agent, disintegrant, lubricating agent or adhesive, then utilizes them to make them into oral analgesic compound tablet or hard capsule preparation.

Description

technical field [0001] The invention relates to an analgesic preparation, in particular to a compound preparation of the analgesic drug tilidine hydrochloride. Background technique [0002] Tiridine hydrochloride is a fully synthetic opioid analgesic drug, which acts on the central nervous system, can selectively inhibit the pain center, has no effect on other sensations, and keeps the patient conscious. It is a narcotic analgesic drug and has dependence. Pain relief for moderate to severe pain. Tiridine hydrochloride is a prodrug, which has no analgesic effect itself, and is almost completely converted into the μ-receptor agonist Nortilidine after the first-pass effect in the liver. It has the effects of analgesia, respiratory inhibition, euphoria, and physical dependence above the spinal cord. Tilidine has the advantages of low dosage, good analgesic effect and little addiction. Its analgesic mechanism is that Nortilidine, the degradation p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/485
Inventor 徐进滑千里王英利赵学刚徐强岳玉敏
Owner 岳振江
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com