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Use of clasping gutweed flavonoid in preparing medicine for treating coronary heart disease

A kind of technology of flavonoids and compounds of Sophora flavonoids, which is applied in the direction of preparation of sugar derivatives, drug combination, cardiovascular system diseases, etc., and can solve the problems that the medical use of coronary heart disease has not been reported in the literature

Inactive Publication Date: 2005-10-19
姜瑞芝 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] According to relevant literature reports, the above-mentioned flavonoids are mainly used in the preparation of drugs such as anti-fatigue, scavenging free radicals, lowering blood fat, weight loss, etc., but there is no report in the literature for the medical use of treating coronary heart disease

Method used

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  • Use of clasping gutweed flavonoid in preparing medicine for treating coronary heart disease
  • Use of clasping gutweed flavonoid in preparing medicine for treating coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of Monomer Compounds

[0048] Get 300kg of the medicinal material Paleopsis cumulus, after decocting and ethanol precipitation to remove impurities, add milk of calcium oxide to make the flavonoids complex with it and precipitate 75kg, suspend the precipitate in ethanol (90%), adjust to Acidic pH = 4, so that the flavonoids are freely dissolved in ethanol, centrifuged to remove insoluble matter, then adjust the ethanol solution to neutral pH = 7, filter out the precipitate, recover the ethanol solution until it has no alcohol smell, and obtain a relative Pure total flavone extract (total flavone content is about 70%) 2100g. Add water to the total flavonoids extract to prepare a concentration of 10g of crude drug per ml, successively elute with distilled water, 30%, 60%, and 95% ethanol through the treated polyamide chromatography column, recover ethanol from each part, and treat with an organic solvent Repeated recrystallization obtained relatively high-pur...

Embodiment 2

[0050] Preparation of Monomer Compounds

[0051] Take 300kg of the medicinal material, Pasternia cumulus, decoct in water and alcohol to precipitate impurities, add calcium oxide milk to make the flavonoids complex with it and precipitate 90kg, suspend the precipitate in ethanol (90%), and adjust it to acidity pH = 4, so that the flavonoids can be freely dissolved in ethanol, centrifuged to remove insoluble matter, then adjust the ethanol solution to neutral pH = 7, filter out the precipitate, recover the ethanol solution until it has no alcohol smell, and obtain a comparative Pure total flavone extract (total flavonoid content is about 70%) 1830g. Add water to the total flavonoids extract to prepare a concentration of 10g of crude drug per ml, elute with 30%, 60%, and 95% ethanol successively through the treated macroporous resin column, recover ethanol from each part, and recrystallize repeatedly after being treated with an organic solvent , to obtain a relatively high puri...

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Abstract

The present invention discloses the application of Ixeris Sonchifolia Hance flavone compounds in preparing medicine for treating coronary heart disease, and the extraction process of Ixeris Sonchifolia Hance flavone compounds and five monomer compounds. Ixeris Sonchifolia Hance flavone compounds applied in medicine for treating coronary heart disease has the features of low toxic side effect, determined curative effect, safety and reliability. The medicine has no negative reactions of bleeding, allergy, causing hypertension, etc.

Description

technical field [0001] The present invention relates to the second medical use of the flavonoids of the genus Aspergillus, discloses its application in the preparation of drugs for the treatment of coronary heart disease, and also provides the flavonoids of the genus asperum and its five monomer compounds The extraction method belongs to the technical field of extracting active ingredients of traditional Chinese medicine and medical application. technical background [0002] The flavonoids extracted and separated from the Compositae plant, Pollenaceae, which are involved in the present invention, have the following general formula: [0003] [0004] Numbering R 1 R 2 R 3 I Oh Oh -CH 2 Oh II Oh Oh -CH 2 O-Glc III Oh -OGlc -CH 2 Oh IV Oh Oh -COOH V H Oh -CH 2 Oh [0005] I Luteolin-7-O-β-D glucoside (luteolin7-glucos...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10C07H1/08C07H17/07
Inventor 高其品姜瑞芝陈英红
Owner 姜瑞芝
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