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Dispersible tablet for activating blood and easing pain and its preparation process

A technology for promoting blood circulation and relieving pain and dispersible tablets, which is applied in the direction of non-central analgesics, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of low quality standard control indicators, inconvenient taking, and few testing data, etc., to achieve The production process is perfect and reasonable, the quality and curative effect are guaranteed, and the effect of quality standard improvement

Inactive Publication Date: 2005-06-29
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the powder has the advantage of acting quickly after taking it, its inaccurate dosage and inconvenient taking are its major defects; although the capsule solves the problem of dosage, it also has a large dosage, and the capsule disintegrates slowly, which affects Disadvantages such as the rapid effect of the drug
At the same time, powders and capsules all have important shortcomings that affect quality, such as low quality standard control indicators in the production process, and few testing data.
Due to the major shortcomings that affect the quality of powders and capsules, we use modern pharmaceutical technology to make major improvements to the product process and form new preparations to ensure product quality control, improve drug efficacy, and benefit the people.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0035] Embodiment 1: The six medicinal herbs are cleaned separately, impurities are removed, and they pass the inspection for later use. Angelica is cut into decoction pieces and the volatile oil is first extracted for later use. The dregs are added with appropriate amount of water and decocted twice, the second decoction liquid is combined, centrifuged, and the suspension is removed. ) liquid extract of Angelica sinensis for subsequent use; the above-mentioned Angelica sinensis volatile oil and cyclodextrin are made into inclusion complexes of Angelica sinensis essential oil and cyclodextrin, and are finely ground for future use. Natural copper (calcined), frankincense (made), ground beetle and notoginseng are mixed and pulverized into fine powder for later use. Take above-mentioned fine powder and appropriate amount of excipients, mix well, add above-mentioned angelica fluid extract to granulate, dry, add borneol, angelica volatile oil β-cyclodextrin inclusion compound and a...

Embodiment approach 2

[0036] Embodiment 2: The six medicinal herbs are cleaned separately, impurities are removed, and they pass the inspection for later use. Angelica sinensis is cut into decoction pieces and the volatile oil is first extracted for later use, and the dregs are added with an appropriate amount of water to decoct twice, the second decoction liquid is combined, centrifuged, the suspension is removed, and the water extract is for later use; the above-mentioned angelica volatile oil and cyclodextrin are made into angelica volatile oil The cyclodextrin inclusion compound is finely ground for later use. Grind the ground beetle into a coarse powder, add an appropriate amount of water and soak it (60-80°C) twice, combine the soaking liquid, centrifuge, and mix the solution after removing the suspended matter with the above-mentioned angelica water extract, and the film is concentrated to a relative density of 1.05-1.15 (50 -60°C) thick extract of Angelica ground beetle for subsequent use. ...

Embodiment approach 3

[0037] Embodiment 3: The six medicinal herbs are cleaned separately, impurities are removed, and they pass the inspection for later use. Angelica sinensis is cut into decoction pieces to extract volatile oil for later use, add appropriate amount of water to decoct the dregs for a second time, combine the second decoction liquid, centrifuge, remove the suspension, and extract the water extract for later use; Grind the dextrin inclusion complex for later use. Grind the ground beetle into a coarse powder, add an appropriate amount of water for soaking (60-80°C) twice, combine the soaking liquids, centrifuge, and mix the solution from which suspended matter is removed with the above-mentioned Angelica water extract, and the film is concentrated to a relative density of 1.05-1.15 (50- 60 ℃) concentrated solution, spray-dried, and collected dry extract powder of angelica wood beetle for later use; natural copper (calcined), frankincense (manufactured), and Panax notoginseng were mix...

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Abstract

The invention provides a dispersible tablet for activating blood and easing pain and its preparation process, which comprises disintegrating the natural copper in the components, coating the borneol, ethanol dissolving into liquid, coating Chinese angelica with cyclodextrin, extracting the dross twice with water, concentrating into extract, disintegrating frankincense and coating with cyclodextrin, water boiling the dross, alcohol depositing to obtain extraction liquor, alcohol extracting the dross again, depositing to obtain precipitation, preparing concentration liquor through disintegrating / water steeping the ground beetle, alcohol extracting Chinese angelica extract and pseudo-ginseng powder, water boiling and alcohol depositing frankincense extraction liquor, spray-drying, charging adjuvant into the material, mixing and tabletting.

Description

technical field [0001] The invention relates to the technical field of manufacturing technology of Chinese patent medicine tablets, in particular to a preparation method of Huoxue Zhitong Dispersible Tablets. Background technique [0002] Dispersible tablets are a new dosage form in traditional Chinese medicine. According to the relevant drug laws and regulations of our country, changing the dosage form is a new drug research. The original dosage forms of Huoxue Zhitong Dispersible Tablets are: Huoxuezhitong Powder and Huoxuezhitong Capsules. And it has been included in the 2000 edition of Pharmacopoeia and Ministry of Standards [WS 3 -091(Z-81)-95(Z)]. The technical characteristics of the original two dosage forms are that all the medicinal materials (six flavors) in the prescription are formed through direct crushing and packaging. Although the powder has the advantage of acting quickly after taking it, its inaccurate dosage and inconvenient takin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P29/00
Inventor 毛友昌毛晓敏
Owner 毛友昌
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