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Novel method for preparing a liver benefiting medicine and its preparation

A technology of Feiliganning tablets and Ganning tablets, which can be used in pill delivery, antiviral agents, pharmaceutical formulations, etc., and can solve the problems of affecting the dissolution rate of active ingredients, limiting clinical application and curative effect, and low drug quality standards , to achieve rich drug varieties, good bioavailability, and good curative effect

Inactive Publication Date: 2005-01-26
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of this capsule is relatively large, 4 capsules at a time, and the bioavailability of this medicine is low. Soluble in water, which affects the dissolution rate of active ingredients in the preparation, limiting its clinical application and curative effect. At the same time, the dosage form is single, and the dosage form is only capsules, and the quality standard of the drug is low, and there is no quantitative index

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: The two medicines are cleaned separately, remove impurities, and pass the inspection for later use; take milk thistle and pulverize into coarse powder for later use; take about 5% of the prescription amount of the medicine and pulverize it into fine powder, and the rest of the medicine are pulverized into coarse powder Standby; crush milk thistle, remove oil, use 80% ethanol as solvent, slowly percolate, collect the filtrate, recover ethanol under reduced pressure, concentrate into paste, and obtain total flavonoids of milk thistle; %, 75%, 50% ethanol gradient extraction, filter, combine the filtrates, concentrate into a thick paste, add the remaining fine powder of the drug, dry, and make a dry extract, add the above-mentioned total flavonoids of milk thistle and appropriate amount of auxiliary materials, and crush , mixed evenly, directly / granulated and compressed into tablets, that is to say.

Embodiment 2

[0032] Embodiment 2: Clean the two herbs respectively, remove impurities, and pass the test for later use; crush the two herbs into coarse powder for later use; take milk thistle and break it, remove the oil, use 80% ethanol as solvent, and slowly percolate , collect the filtrate, recover ethanol under reduced pressure, and concentrate to an appropriate amount for later use; the coarse powder of the drug is extracted with ethanol gradients of 95%, 75%, and 50%, respectively, filtered, and the filtrates are combined, concentrated to an appropriate amount, and combined with the above-mentioned concentrated solution, Spray drying, collect dry cream powder, mix with appropriate amount of auxiliary materials, directly / granulate and press into tablets to obtain.

Embodiment 3

[0033] Embodiment 3: The two herbs are cleaned separately, impurities are removed, and they pass the test for later use; the two herbs are respectively pulverized into coarse powder for later use; milk thistle is taken and broken, and after degreasing, use 80% ethanol as a solvent to heat and reflux to extract 3 times , combine the extracts, recover ethanol under reduced pressure, concentrate to an appropriate amount for later use; use 95% ethanol as a coarse powder to heat and extract twice, filter the extract, combine the filtrates, recover ethanol, and concentrate to an appropriate amount for later use; decoct the medicinal residues with water Boil twice, filter the medicinal liquid, concentrate to an appropriate amount, combine with the above-mentioned milk thistle and the concentrated medicinal liquid, spray dry, collect the dry paste powder, mix with appropriate amount of auxiliary materials, directly / granulate and press into tablets, that is have to.

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PUM

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Abstract

The invention provides a novel method for preparing a liver benefiting medicine and its preparation, wherein process modification is introduced into the conventional capsule production process, which overcomes the shortcoming of large administration amount and low biological availability.

Description

technical field [0001] The invention relates to the technical field of manufacturing technology of Chinese patent medicine tablets, in particular to Dangfei Liganning tablets and a preparation method thereof. Background technique [0002] Tablet is a commonly used dosage form. According to the relevant drug laws and regulations of our country, changing the dosage form is regarded as a new drug research. The original dosage form of Dangfei Liganning Tablet is Dangfei Liganning Capsule, which has been included in the Ministry of Health of the People's Republic of China. In the seventeenth volume of standard traditional Chinese medicine prescription preparations, it is a national essential medicine and a Chinese medicine variety that is promoted by the country. The medicine is composed of milk thistle and two traditional Chinese medicines. It has the functions of clearing away dampness and heat, benefiting the liver and reducing jaundice. It is used for j...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61P1/16A61P31/12
Inventor 毛友昌毛小敏
Owner 毛友昌
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