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Troxerutin powder injection

A technology of troxerutin and powder injection, which is applied in the field of medicine, can solve the problems of unstable preparations, inconvenient storage and transportation, etc., and achieve the effect of convenient clinical use, convenient storage and transportation, and long time

Inactive Publication Date: 2005-03-02
广东阳江制药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, it has achieved good curative effect in the treatment of ischemic cerebrovascular disease, central retinitis, arteriosclerosis, thrombophlebitis, varicose veins, occlusive syndrome, capillary hemorrhage and edema caused by increased vascular permeability At present, troxerutin injections are marketed as water injections and infusions. However, water injections and infusions cause inconvenience to storage and transportation, and troxerutin sodium chloride injection is listed in the "Chemical Drugs Local Standards Upgrading National Standards". "The precautions in the instruction manual clearly stated: Please check this product in detail before use. If the solution is cloudy, please do not use it.
It can be seen that the instability of its preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A troxerutin powder injection comprises troxerutin and an excipient, wherein the excipient is mannitol.

[0014] The powder injection of this embodiment comprises the medicine of following percentage by weight:

[0015] Troxerutin 2.44

[0016] Mannitol 97.56

[0017] The preparation method of this embodiment powder injection is as follows:

[0018] Measure 5 g of troxerutin raw material, add 1.5 L of water for injection, stir to dissolve, add 200 g of mannitol, stir to dissolve, add additional water for injection to 2 L, add charcoal for needles, stir at room temperature, filter for decarbonization, and fine filter. The filtrate is divided into 5ml bottles, and freeze-dried to obtain a sterile freeze-dried product of troxerutin.

Embodiment 2

[0020] A troxerutin powder injection comprises troxerutin as medicine.

[0021] The powder injection of this embodiment comprises the medicine of following percentage by weight:

[0022] Troxerutin 100

[0023] Its preparation method is with embodiment 1.

Embodiment 3

[0025] A troxerutin powder injection comprises troxerutin and an excipient, wherein the excipient is lactose.

[0026] The powder injection of this embodiment comprises the medicine of following percentage by weight:

[0027] Troxerutin 50

[0028] Lactose 50

[0029] The preparation method of this embodiment is as follows:

[0030] Take 150g of troxerutin raw material, add 3.0L of water for injection, stir to dissolve, add 150g of lactose, stir to dissolve, add water for injection to 4L, add charcoal for needles, stir at room temperature, filter for decarbonization, and fine filter. The filtrate was spray-dried to obtain troxerutin sterile powder. Then carry out aseptic sub-packaging by 150 mg (calculated as Troxerutin) per bottle to obtain Troxerutin powder injection.

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PUM

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Abstract

The troxerutin powder for injection includes troxerutin 2-100 wt% and excipient 0-98 wt%, and the excipient is one of mannitol, lactose, glycine, sorbic alcohol, low molecular weight dextran, glucose, cane sugar and hydrolysate gel. It is bacteria-free powder or bacteria-free freeze dried produce. The present invention is used in treating ischemic cerebral vascular diseases, central retinitis, arteriosclerosis, thrombotic phlebitis, varicosity, etc. and has the advantages of stability, fast dissolution in water and high safety.

Description

(1) Technical field [0001] The invention relates to the technical field of medicine, in particular to a troxerutin powder injection. (2) Background technology [0002] Troxerutin can inhibit platelet aggregation and prevent thrombosis. At the same time, it can resist vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability. Clinically, it has achieved good curative effect in the treatment of ischemic cerebrovascular disease, central retinitis, arteriosclerosis, thrombophlebitis, varicose veins, occlusive syndrome, capillary hemorrhage and edema caused by increased vascular permeability At present, troxerutin injections are marketed as water injections and infusions. However, water injections and infusions bring inconvenience to storage and transportation, and troxerutin sodium chloride injection is listed in the "Chemical Drugs Local Standards Upgra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/352A61P7/02A61P9/00A61P9/10
Inventor 刘铁球
Owner 广东阳江制药厂有限公司
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