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Injection emulsion of oil of zedoary turmeric, and preparation method

A technology of zedoary turmeric oil and emulsion, which can be used in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of human cardiovascular and cerebrovascular toxicity and other problems

Inactive Publication Date: 2005-01-12
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of Tween substances in injection preparations, especially in traditional Chinese medicine injection preparations, can cause toxic reactions in the human cardiovascular and cerebrovascular systems.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 1.0g of turmeric oil and 12g of refined soybean lecithin in 100g of refined soybean oil, dissolve 22.5g of glycerin in water for injection, heat to 55℃ respectively, mix well, first disperse and emulsify in a tissue masher for 3-4 minutes After that, it is emulsified by a high-speed milk homogenizer until the milk particles meet the requirements of the Pharmacopoeia (the milk particles below 2μm should not be less than 95%, and the milk particles above 5μm shall not be detected), add water for injection to 1000ml, adjust the pH value to 5.5-9.0, Cool, collect the emulsion in an infusion bottle, and sterilize it to obtain the turmeric oil injection emulsion. This process is a 1000ml prescription, the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0022] Add 6g of refined egg yolk lecithin to 50g of xylitol solution, heat it to 70°C, first use a tissue masher to stir 3 times at 8000-12000 rpm for dispersion, then add 4.0g of turmeric oil and refined soybean oil Add 50g of oil solution, stir 3 times at the same speed for emulsification and dispersion, then emulsify by a high-speed homogenizer to meet the pharmacopoeia regulations (same example 1), add water for injection to a sufficient amount, cool the emulsion, and collect it in an infusion bottle After sterilization, turmeric oil injection emulsion can be obtained.

[0023] The antiviral test in vitro was carried out with the zedoary turmeric oil injection emulsion of Example 2 of the present invention.

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PUM

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Abstract

An emulsified zedoary oil injection is prepared from zedoary oil, plant oil for injection, emulsifier and isotonic regulator through dissolving zedoary oil and emulsifir in plant oil for injection, mixing with isotonic regulator and the water for injection, and emulsifying at 35-95 deg.c. It can be used for treating viral disease, tumor and thrombus.

Description

Technical field [0001] The invention relates to a turmeric oil injection emulsion and a preparation method thereof. The drug can be used for the treatment of antiviral, antitumor and antithrombotic diseases. Background technique [0002] Curcuma is the rhizome of Curcuma aromatica Salisb (usually called Curcuma). Turmeric oil is the volatile oil component contained in it. It can be distilled by traditional steam or CO 2 Obtained by other methods such as supercritical extraction. Clinically, the volatile oil component can be used for anti-virus, anti-thrombosis and anti-tumor, etc., and has satisfactory curative effect. At present, the injection-type pharmaceutical preparations using the volatile oil as the effective drug ingredient include turmeric oil injection and elemene emulsion. Among the injections are turmeric oil injection, turmeric oil glucose injection (only applicable to children with viral pneumonia), which is a transparent injection made with Tween-80 as a solvent, a...

Claims

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Application Information

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IPC IPC(8): A61P7/02A61P31/12A61P35/00
Inventor 欧苏黄英华郁东梅梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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