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Drip pill medicine composition for treating diabetes and its complication and productive method thereof

A composition and complication technology, applied in the direction of drug combination, heterocyclic compound active ingredients, pill delivery, etc., can solve the problems of low inhibitory concentration, short-lived, only trace amount left after 24 hours, poor oral absorption, etc., to achieve drug High stability, not easily hydrolyzed, less side effects

Inactive Publication Date: 2004-05-05
孔繁立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this drug has poor oral absorption, the injection source quickly enters various organs and tissues, the blood drug concentration is maintained for a short time, lower than the minimum inhibitory concentration, and the retention time in the tissue is short, only a trace amount remains after 24 hours, most The drug is metabolized and cleared in the body, and the excretion of the original form within 48 hours only accounts for less than 5% of the administered dose

Method used

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  • Drip pill medicine composition for treating diabetes and its complication and productive method thereof
  • Drip pill medicine composition for treating diabetes and its complication and productive method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The pharmaceutical composition includes 60-90 parts by weight of berberine hydrochloride and 300-380 parts by weight of PEG4000 base.

Embodiment 2

[0024] The pharmaceutical composition includes 70-80 parts by weight of berberine hydrochloride and 320-340 parts by weight of PEG4000 base. The matrix refers to

[0025] With reference to the attached drawings, the production method of the medicine composition dripping pills for the treatment of diabetes and its complications is carried out in sequence according to the following steps:

[0026] a. Weigh 300-380 parts by weight of PEG4000 matrix and place it in an oil bath container and heat it at 90℃-95℃;

[0027] b. Weigh 60-90 parts of berberine hydrochloride, pulverize, pass through a 180-mesh sieve, and then add it to the oil bath container;

[0028] c. Stir continuously with a mixer to melt all the berberine hydrochloride;

[0029] d. Filter while it is hot, and place the filtrate in a storage tank with a holding temperature of 95°C for standby;

[0030] e. Use a 40mg dripper on the dripper machine to drop the above-mentioned spare liquid medicine into the liquid paraffin. A...

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Abstract

A composite dripping pill for treating diabetes and its complications is prepared from berberine hydrochloride 60-90 portions and matrix PEG 4000 300-380 portions through proportioning, thermally fusing, dripping, cooling, washing, coating and drying. Its advantages are high curative effect up to 92%, high biological utilization rate and stability, and easy absorption.

Description

1. Technical Field [0001] The invention relates to a dripping pill medicinal composition for treating diabetes and its complications and a production method. 2. Background technology [0002] Berberine hydrochloride, also known as berberine hydrochloride, is in tablet form and is mainly used for intestinal infections such as gastroenteritis and bacillary dysentery caused by sensitive pathogens. The pharmacodynamics of the drug is broad antibacterial spectrum, and it has inhibitory effect on a variety of gram-positive and gram-negative bacteria in vitro, including streptococcus hemolyticus, Staphylococcus aureus, Vibrio cholerae, meningococcus, Shiga , Typhoid bacillus, Diphtheria bacillus, etc. have a strong inhibitory effect. However, this drug has poor oral absorption. The original injection quickly enters various organs and tissues. The blood concentration is maintained for a short time, below the minimum inhibitory concentration. The residence time in the tissue is short, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/43A61P3/10
Inventor 孔繁立
Owner 孔繁立
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